d-Alanine: Distribution, origin, physiological relevance, and implications in disease.
Alanine
/ metabolism
Animals
Diabetes Mellitus
/ metabolism
Humans
Kidney Diseases
/ metabolism
Liver Cirrhosis
/ metabolism
Mental Disorders
/ metabolism
Neoplasms
/ metabolism
Nervous System Diseases
/ metabolism
Ocular Hypertension
/ metabolism
Short Bowel Syndrome
/ metabolism
Smoking
/ metabolism
Chiral metabolites
Disease
Host-microbe
NMDA receptor
d-alanine
d-amino acids
Journal
Biochimica et biophysica acta. Proteins and proteomics
ISSN: 1878-1454
Titre abrégé: Biochim Biophys Acta Proteins Proteom
Pays: Netherlands
ID NLM: 101731734
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
28
05
2020
revised:
19
06
2020
accepted:
29
06
2020
pubmed:
9
7
2020
medline:
15
12
2020
entrez:
9
7
2020
Statut:
ppublish
Résumé
d-Alanine (d-Ala) is an unusual endogenous amino acid present in invertebrates and vertebrates. Compared to its l-isomer, the characterization of d-Ala is challenging because of the need for chiral resolution and the low amounts of the d-enantiomer present. With recent improvements in measurement capabilities, research on d-Ala, along with other d-amino acids, has been growing, especially as the functional significance of d-Ala in the mammalian nervous and endocrine systems is becoming known. Here we provide an overview of the distribution, origin, function, and disease implications of d-Ala.
Identifiants
pubmed: 32640293
pii: S1570-9639(20)30129-1
doi: 10.1016/j.bbapap.2020.140482
pii:
doi:
Substances chimiques
Alanine
OF5P57N2ZX
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
140482Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.