The effect of ellagic acid on spinal cord and sciatica function in a mice model of multiple sclerosis.
Animals
Behavior, Animal
/ drug effects
Cytokines
/ metabolism
Disease Models, Animal
Dose-Response Relationship, Drug
Ellagic Acid
/ administration & dosage
Inflammation Mediators
/ metabolism
Male
Mice
Mice, Inbred C57BL
Multiple Sclerosis
/ metabolism
Neuroprotective Agents
/ administration & dosage
Oxidative Stress
/ drug effects
Sciatica
/ metabolism
Spinal Cord
/ drug effects
cuprizone
ellagic acid
multiple sclerosis
oxidative stress
sciatica
spinal cord
Journal
Journal of biochemical and molecular toxicology
ISSN: 1099-0461
Titre abrégé: J Biochem Mol Toxicol
Pays: United States
ID NLM: 9717231
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
16
02
2020
revised:
08
05
2020
accepted:
17
06
2020
pubmed:
9
7
2020
medline:
24
6
2021
entrez:
9
7
2020
Statut:
ppublish
Résumé
Multiple sclerosis (MS) is a well-known neurodegenerative disorder, causing toxicity in different organs, such as spinal cord tissue. The goal of this study was to investigate the protective effect of ellagic acid (EA) against spinal cord and sciatica function in cuprizone (Cup)-induced demyelination model. Animals were divided into six equal groups. The first group received tap water as the control. Cup group was treated with Cup (0.2% w/w in fed). EA 100 group was orally treated with EA (100 mg/kg). EA + Cup groups were orally treated with three doses of 5, 50, and 100 mg/kg of EA plus Cup (0.2% w/w). All groups received treatment for 42 days. Open field, rotarod, and gait tests were done to evaluate the behavioral changes following Cup and/or EA treatment. Also, lipid peroxidation, reactive oxygen species (ROS) content, antioxidant capacity, superoxide dismutase (SOD), and catalase enzymes activity in spinal cord was evaluated. Luxol fast blue (LFB) staining also the behavioral tests were performed to evaluate the model. Cup increased ROS levels and oxidative stress in their spinal cord tissues. Also, Cup reduced antioxidant capacity, SOD, and catalase activity. EA (especially at 100 mg/kg) prevented these abnormal changes. EA co-treatment dose-dependently was able to ameliorate behavioral impairments in mice that received Cup. EA might act as a protective agent in MS by modulating spinal cord function.
Substances chimiques
Cytokines
0
Inflammation Mediators
0
Neuroprotective Agents
0
Ellagic Acid
19YRN3ZS9P
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e22564Subventions
Organisme : Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Iran
ID : 97-01-36-17138
Informations de copyright
© 2020 Wiley Periodicals LLC.
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