Extracellular ATP and CD39 Activate cAMP-Mediated Mitochondrial Stress Response to Promote Cytarabine Resistance in Acute Myeloid Leukemia.
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
30
08
2019
revised:
09
05
2020
accepted:
02
07
2020
pubmed:
10
7
2020
medline:
20
11
2021
entrez:
10
7
2020
Statut:
ppublish
Résumé
Relapses driven by chemoresistant leukemic cell populations are the main cause of mortality for patients with acute myeloid leukemia (AML). Here, we show that the ectonucleotidase CD39 (ENTPD1) is upregulated in cytarabine-resistant leukemic cells from both AML cell lines and patient samples
Identifiants
pubmed: 32641297
pii: 2159-8290.CD-19-1008
doi: 10.1158/2159-8290.CD-19-1008
doi:
Substances chimiques
Antigens, CD
0
Cytarabine
04079A1RDZ
Apyrase
EC 3.6.1.5
CD39 antigen
EC 3.6.1.5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1544-1565Informations de copyright
©2020 American Association for Cancer Research.
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