Cerebrovascular reactivity in cerebral amyloid angiopathy, Alzheimer disease, and mild cognitive impairment.

Aged Alzheimer Disease / physiopathology Cerebral Amyloid Angiopathy / physiopathology Cerebrovascular Circulation / physiology Cognitive Dysfunction / physiopathology Cohort Studies Cross-Sectional Studies Echo-Planar Imaging Evoked Potentials, Visual / physiology Female Humans Image Interpretation, Computer-Assisted / methods Male Middle Aged Prospective Studies Visual Cortex / physiopathology

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
08 09 2020
Historique:
received: 26 06 2019
accepted: 16 03 2020
pubmed: 10 7 2020
medline: 23 10 2020
entrez: 10 7 2020
Statut: ppublish

Résumé

To assess cerebrovascular reactivity in response to a visual task in participants with cerebral amyloid angiopathy (CAA), Alzheimer disease (AD), and mild cognitive impairment (MCI) using fMRI. This prospective cohort study included 40 patients with CAA, 22 with AD, 27 with MCI, and 25 healthy controls. Each participant underwent a visual fMRI task using a contrast-reversing checkerboard stimulus. Visual evoked potentials (VEPs) were used to compare visual cortex neuronal activity in 83 participants. General linear models using least-squares means, adjusted for multiple comparisons with the Tukey test, were used to estimate mean blood oxygen level-dependent (BOLD) signal change during the task and VEP differences between groups. After adjustment for age and hypertension, estimated mean BOLD response amplitude was as follows: CAA 1.88% (95% confidence interval [CI] 1.60%-2.15%), AD 2.26% (1.91%-2.61%), MCI 2.15% (1.84%-2.46%), and control 2.65% (2.29%-3.00%). Only patients with CAA differed from controls ( Mean visual BOLD response amplitude was lowest in participants with CAA compared to controls, without differences in VEP latencies and amplitudes. This suggests that the impaired visual BOLD response is due to reduced vascular reactivity in CAA. In contrast to participants with CAA, the visual BOLD response amplitude did not differ between those with AD or MCI and controls.

Identifiants

DOI: 10.1212/WNL.0000000000010201 PMID: 32641520 PMC: PMC7538216
pubmed: 32641520
pii: WNL.0000000000010201
doi: 10.1212/WNL.0000000000010201
pmc: PMC7538216
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e1333-e1340

Subventions

Organisme : CIHR
Pays : Canada

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2020 American Academy of Neurology.

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Auteurs

Aaron R Switzer (AR)

From the Department of Clinical Neurosciences (A.R.S., C.R.M., A.Z., A.C., A.A.-V., R.S., C.Z., R.B.S., R.F., B.G.G., E.E.S), Hotchkiss Brain Institute (R.F., B.G.G., E.E.S), Department of Community Health Sciences (C.Z., E.E.S), and Department of Radiology (R.F., B.G.G., E.E.S), University of Calgary, Alberta; Faculty of Medicine (I.C.), University of Toronto, Ontario; and Seaman Family MR Research Centre (C.R.M., R.F., B.G.G.), Foothills Medical Centre, Calgary, Alberta, Canada.

Ikreet Cheema (I)

From the Department of Clinical Neurosciences (A.R.S., C.R.M., A.Z., A.C., A.A.-V., R.S., C.Z., R.B.S., R.F., B.G.G., E.E.S), Hotchkiss Brain Institute (R.F., B.G.G., E.E.S), Department of Community Health Sciences (C.Z., E.E.S), and Department of Radiology (R.F., B.G.G., E.E.S), University of Calgary, Alberta; Faculty of Medicine (I.C.), University of Toronto, Ontario; and Seaman Family MR Research Centre (C.R.M., R.F., B.G.G.), Foothills Medical Centre, Calgary, Alberta, Canada.

Cheryl R McCreary (CR)

From the Department of Clinical Neurosciences (A.R.S., C.R.M., A.Z., A.C., A.A.-V., R.S., C.Z., R.B.S., R.F., B.G.G., E.E.S), Hotchkiss Brain Institute (R.F., B.G.G., E.E.S), Department of Community Health Sciences (C.Z., E.E.S), and Department of Radiology (R.F., B.G.G., E.E.S), University of Calgary, Alberta; Faculty of Medicine (I.C.), University of Toronto, Ontario; and Seaman Family MR Research Centre (C.R.M., R.F., B.G.G.), Foothills Medical Centre, Calgary, Alberta, Canada.

Angela Zwiers (A)

From the Department of Clinical Neurosciences (A.R.S., C.R.M., A.Z., A.C., A.A.-V., R.S., C.Z., R.B.S., R.F., B.G.G., E.E.S), Hotchkiss Brain Institute (R.F., B.G.G., E.E.S), Department of Community Health Sciences (C.Z., E.E.S), and Department of Radiology (R.F., B.G.G., E.E.S), University of Calgary, Alberta; Faculty of Medicine (I.C.), University of Toronto, Ontario; and Seaman Family MR Research Centre (C.R.M., R.F., B.G.G.), Foothills Medical Centre, Calgary, Alberta, Canada.

Anna Charlton (A)

From the Department of Clinical Neurosciences (A.R.S., C.R.M., A.Z., A.C., A.A.-V., R.S., C.Z., R.B.S., R.F., B.G.G., E.E.S), Hotchkiss Brain Institute (R.F., B.G.G., E.E.S), Department of Community Health Sciences (C.Z., E.E.S), and Department of Radiology (R.F., B.G.G., E.E.S), University of Calgary, Alberta; Faculty of Medicine (I.C.), University of Toronto, Ontario; and Seaman Family MR Research Centre (C.R.M., R.F., B.G.G.), Foothills Medical Centre, Calgary, Alberta, Canada.

Ana Alvarez-Veronesi (A)

From the Department of Clinical Neurosciences (A.R.S., C.R.M., A.Z., A.C., A.A.-V., R.S., C.Z., R.B.S., R.F., B.G.G., E.E.S), Hotchkiss Brain Institute (R.F., B.G.G., E.E.S), Department of Community Health Sciences (C.Z., E.E.S), and Department of Radiology (R.F., B.G.G., E.E.S), University of Calgary, Alberta; Faculty of Medicine (I.C.), University of Toronto, Ontario; and Seaman Family MR Research Centre (C.R.M., R.F., B.G.G.), Foothills Medical Centre, Calgary, Alberta, Canada.

Ramnik Sekhon (R)

From the Department of Clinical Neurosciences (A.R.S., C.R.M., A.Z., A.C., A.A.-V., R.S., C.Z., R.B.S., R.F., B.G.G., E.E.S), Hotchkiss Brain Institute (R.F., B.G.G., E.E.S), Department of Community Health Sciences (C.Z., E.E.S), and Department of Radiology (R.F., B.G.G., E.E.S), University of Calgary, Alberta; Faculty of Medicine (I.C.), University of Toronto, Ontario; and Seaman Family MR Research Centre (C.R.M., R.F., B.G.G.), Foothills Medical Centre, Calgary, Alberta, Canada.

Charlotte Zerna (C)

From the Department of Clinical Neurosciences (A.R.S., C.R.M., A.Z., A.C., A.A.-V., R.S., C.Z., R.B.S., R.F., B.G.G., E.E.S), Hotchkiss Brain Institute (R.F., B.G.G., E.E.S), Department of Community Health Sciences (C.Z., E.E.S), and Department of Radiology (R.F., B.G.G., E.E.S), University of Calgary, Alberta; Faculty of Medicine (I.C.), University of Toronto, Ontario; and Seaman Family MR Research Centre (C.R.M., R.F., B.G.G.), Foothills Medical Centre, Calgary, Alberta, Canada.

Randall B Stafford (RB)

From the Department of Clinical Neurosciences (A.R.S., C.R.M., A.Z., A.C., A.A.-V., R.S., C.Z., R.B.S., R.F., B.G.G., E.E.S), Hotchkiss Brain Institute (R.F., B.G.G., E.E.S), Department of Community Health Sciences (C.Z., E.E.S), and Department of Radiology (R.F., B.G.G., E.E.S), University of Calgary, Alberta; Faculty of Medicine (I.C.), University of Toronto, Ontario; and Seaman Family MR Research Centre (C.R.M., R.F., B.G.G.), Foothills Medical Centre, Calgary, Alberta, Canada.

Richard Frayne (R)

From the Department of Clinical Neurosciences (A.R.S., C.R.M., A.Z., A.C., A.A.-V., R.S., C.Z., R.B.S., R.F., B.G.G., E.E.S), Hotchkiss Brain Institute (R.F., B.G.G., E.E.S), Department of Community Health Sciences (C.Z., E.E.S), and Department of Radiology (R.F., B.G.G., E.E.S), University of Calgary, Alberta; Faculty of Medicine (I.C.), University of Toronto, Ontario; and Seaman Family MR Research Centre (C.R.M., R.F., B.G.G.), Foothills Medical Centre, Calgary, Alberta, Canada.
ORCID: 0000-0003-0358-1210

Bradley G Goodyear (BG)

From the Department of Clinical Neurosciences (A.R.S., C.R.M., A.Z., A.C., A.A.-V., R.S., C.Z., R.B.S., R.F., B.G.G., E.E.S), Hotchkiss Brain Institute (R.F., B.G.G., E.E.S), Department of Community Health Sciences (C.Z., E.E.S), and Department of Radiology (R.F., B.G.G., E.E.S), University of Calgary, Alberta; Faculty of Medicine (I.C.), University of Toronto, Ontario; and Seaman Family MR Research Centre (C.R.M., R.F., B.G.G.), Foothills Medical Centre, Calgary, Alberta, Canada.

Eric E Smith (EE)

From the Department of Clinical Neurosciences (A.R.S., C.R.M., A.Z., A.C., A.A.-V., R.S., C.Z., R.B.S., R.F., B.G.G., E.E.S), Hotchkiss Brain Institute (R.F., B.G.G., E.E.S), Department of Community Health Sciences (C.Z., E.E.S), and Department of Radiology (R.F., B.G.G., E.E.S), University of Calgary, Alberta; Faculty of Medicine (I.C.), University of Toronto, Ontario; and Seaman Family MR Research Centre (C.R.M., R.F., B.G.G.), Foothills Medical Centre, Calgary, Alberta, Canada eesmith@ucalgary.ca.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Cerebrovascular reactivity in cerebral amyloid...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Cerebrovascular reactivity in cerebral amyloid...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Amyloïdose › Angiopathie amyloïde cérébrale › Cerebrovascular reactivity in cerebral amyloid...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Circulation sanguine › Circulation cérébrovasculaire › Cerebrovascular reactivity in cerebral amyloid...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Cerebrovascular reactivity in cerebral amyloid...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Cerebrovascular reactivity in cerebral amyloid...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Cerebrovascular reactivity in cerebral amyloid...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Imagerie échoplanaire › Cerebrovascular reactivity in cerebral amyloid...
questionsmedicales.fr › Phénomènes physiologiques oculaires › Potentiels évoqués visuels › Cerebrovascular reactivity in cerebral amyloid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cerebrovascular reactivity in cerebral amyloid...
questionsmedicales.fr › Sciences de l'information › Informatique › Informatique médicale › Applications de l'informatique médicale › Prise de décision assistée par ordinateur › Diagnostic assisté par ordinateur › Interprétation d'images assistée par ordinateur › Cerebrovascular reactivity in cerebral amyloid...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Cerebrovascular reactivity in cerebral amyloid...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Cerebrovascular reactivity in cerebral amyloid...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Cortex sensorimoteur › Cortex visuel › Cerebrovascular reactivity in cerebral amyloid...