Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling.

Active Transport, Cell Nucleus Amino Acid Motifs Biotinylation Calcineurin / metabolism Centrosome / metabolism Computer Simulation HEK293 Cells HeLa Cells Humans Mass Spectrometry Nuclear Pore Complex Proteins / metabolism Phosphoric Monoester Hydrolases / chemistry Phosphorylation Protein Interaction Maps Proteome / metabolism Receptor, Notch1 / metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins / metabolism Signal Transduction
NPC Notch1 ProP-PD SLiM Short Linear Motif calcineurin calcium signaling centrosome in silico motif discovery nuclear pore complex protein phosphatase proteomic peptide phage display proximity-dependent biotinylation

Journal

Molecular cell
ISSN: 1097-4164
Titre abrégé: Mol Cell
Pays: United States
ID NLM: 9802571

Informations de publication

Date de publication:
16 07 2020
Historique:
received: 10 07 2019
revised: 24 03 2020
accepted: 26 05 2020
pubmed: 10 7 2020
medline: 1 9 2020
entrez: 10 7 2020
Statut: ppublish

Résumé

Short linear motifs (SLiMs) drive dynamic protein-protein interactions essential for signaling, but sequence degeneracy and low binding affinities make them difficult to identify. We harnessed unbiased systematic approaches for SLiM discovery to elucidate the regulatory network of calcineurin (CN)/PP2B, the Ca

Identifiants

DOI: 10.1016/j.molcel.2020.06.029 PMID: 32645368 PMC: PMC7416808
pubmed: 32645368
pii: S1097-2765(20)30431-7
doi: 10.1016/j.molcel.2020.06.029
pmc: PMC7416808
mid: NIHMS1607869
pii:
doi:

Substances chimiques

NOTCH1 protein, human 0
NUP153 protein, human 0
Nuclear Pore Complex Proteins 0
Proteome 0
Receptor, Notch1 0
Saccharomyces cerevisiae Proteins 0
calcineurin phosphatase EC 3.1.3.-
Calcineurin EC 3.1.3.16
Phosphoric Monoester Hydrolases EC 3.1.3.2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

342-358.e12

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM135706
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM119336
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM130286
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007276
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM131052
Pays : United States
Organisme : CIHR
ID : FDN143301
Pays : Canada
Organisme : NIGMS NIH HHS
ID : F32 GM120916
Pays : United States
Organisme : NIGMS NIH HHS
ID : K99 GM131024
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM136243
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

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Auteurs

Callie P Wigington (CP)

Department of Biology, Stanford University, Stanford, CA, USA.

Jagoree Roy (J)

Department of Biology, Stanford University, Stanford, CA, USA.

Nikhil P Damle (NP)

Department of Biology, Stanford University, Stanford, CA, USA.

Vikash K Yadav (VK)

Department of Chemistry - BMC, Uppsala University, Uppsala, Sweden.

Cecilia Blikstad (C)

Department of Chemistry - BMC, Uppsala University, Uppsala, Sweden.

Eduard Resch (E)

Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch for Translational Medicine and Pharmacology TMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.

Cassandra J Wong (CJ)

Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

Douglas R Mackay (DR)

Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.

Jennifer T Wang (JT)

Department of Biology, Stanford University, Stanford, CA, USA.

Izabella Krystkowiak (I)

Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.

Devin A Bradburn (DA)

Department of Biology, Stanford University, Stanford, CA, USA.

Eirini Tsekitsidou (E)

Department of Biology, Stanford University, Stanford, CA, USA.

Su Hyun Hong (SH)

Department of Plant Biology, Carnegie Institution for Science, Stanford, CA, USA.

Malika Amyn Kaderali (MA)

Department of Plant Biology, Carnegie Institution for Science, Stanford, CA, USA.

Shou-Ling Xu (SL)

Department of Plant Biology, Carnegie Institution for Science, Stanford, CA, USA.

Tim Stearns (T)

Department of Biology, Stanford University, Stanford, CA, USA.

Anne-Claude Gingras (AC)

Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, M5S 3H7 ON, Canada.

Katharine S Ullman (KS)

Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.

Ylva Ivarsson (Y)

Department of Chemistry - BMC, Uppsala University, Uppsala, Sweden.

Norman E Davey (NE)

Division of Cancer Biology, The Institute of Cancer Research, 237 Fullham Road, London SW3 6JB, UK.

Martha S Cyert (MS)

Department of Biology, Stanford University, Stanford, CA, USA. Electronic address: mcyert@stanford.edu.

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Transport biologique › Transport des protéines › Transport nucléaire actif › Systematic Discovery of Short Linear Motifs...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › Motifs d'acides aminés › Systematic Discovery of Short Linear Motifs...
questionsmedicales.fr › Métabolisme › Biotinylation › Systematic Discovery of Short Linear Motifs...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphoprotein Phosphatases › Calcineurine › Systematic Discovery of Short Linear Motifs...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Cytosquelette › Appareil du fuseau › Pôles du fuseau › Centrosome › Systematic Discovery of Short Linear Motifs...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Systematic Discovery of Short Linear Motifs...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Systematic Discovery of Short Linear Motifs...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HeLa › Systematic Discovery of Short Linear Motifs...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Systematic Discovery of Short Linear Motifs...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Systematic Discovery of Short Linear Motifs...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs nucléocytoplasmiques › Complexe protéique du pore nucléaire › Systematic Discovery of Short Linear Motifs...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Phosphoric monoester hydrolases › Systematic Discovery of Short Linear Motifs...
questionsmedicales.fr › Métabolisme › Phosphorylation › Systematic Discovery of Short Linear Motifs...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Cartes d'interactions protéiques › Systematic Discovery of Short Linear Motifs...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéome › Systematic Discovery of Short Linear Motifs...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Récepteurs Notch › Récepteur Notch1 › Systematic Discovery of Short Linear Motifs...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Systematic Discovery of Short Linear Motifs...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Saccharomyces cerevisiae › Systematic Discovery of Short Linear Motifs...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Systematic Discovery of Short Linear Motifs...