Evaluation of N-terminal prohormone of brain natriuretic peptide and cardiac troponin-I levels in cats with systolic anterior motion of the mitral valve in the absence of left ventricular hypertrophy.
Animals
Biomarkers
/ blood
Cat Diseases
/ blood
Cats
Female
Hypertrophy, Left Ventricular
/ veterinary
Male
Mitral Valve
/ physiopathology
Natriuretic Peptide, Brain
/ blood
Peptide Fragments
/ blood
Predictive Value of Tests
Retrospective Studies
Systole
Troponin I
/ blood
Ventricular Outflow Obstruction
/ blood
Dynamic outflow tract obstruction
Feline
NT-proBNP
cTnI
Journal
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology
ISSN: 1875-0834
Titre abrégé: J Vet Cardiol
Pays: Netherlands
ID NLM: 101163270
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
30
11
2019
revised:
05
05
2020
accepted:
06
05
2020
pubmed:
10
7
2020
medline:
7
4
2021
entrez:
10
7
2020
Statut:
ppublish
Résumé
To identify the prevalence of systolic anterior motion of the mitral valve (SAM) in apparently healthy cats in the absence of left ventricular hypertrophy (LVH) and examine the relationship between specific cardiac biomarker concentrations and echocardiographic parameters in these individuals. eighty client-owned cats. retrospective study; inclusion criteria were the presence of SAM on conscious echocardiography and concurrent measurement of plasma N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and serum cardiac troponin-I (cTnI). Cats were excluded if they had LVH, left atrial enlargement or systemic disease. The percentages of cats with NT-proBNP and cTnI concentrations above the normal reference range were calculated. The correlation between each biomarker concentration and left ventricular myocardial wall thickness, left atrial size and maximum left ventricular outflow tract velocity was evaluated. Thirty-four of 80 patients with SAM showed no evidence of cardiac remodelling (LVH or left atrial enlargement). Of these patients, 30 of 34 had elevated NT-proBNP, and cTnI was elevated in 13 of 27 (48.1%) cats where this biomarker was measured in association with the NT-proBNP assay. A positive correlation was observed between concentration of plasma NT-proBNP and maximum left ventricular outflow tract velocity (rs = 0.67, p<0.0001). No significant correlations were found between the concentration of biomarkers and the remaining echocardiographic parameters. SAM is frequently observed in cats even in the absence of cardiac remodelling, and these individuals often demonstrate elevated plasma NT-proBNP and serum cTnI concentrations. Plasma NT-proBNP elevation is correlated with the severity of the left ventricular outflow obstruction caused by SAM.
Identifiants
pubmed: 32645686
pii: S1760-2734(20)30045-X
doi: 10.1016/j.jvc.2020.05.001
pii:
doi:
Substances chimiques
Biomarkers
0
Peptide Fragments
0
Troponin I
0
pro-brain natriuretic peptide (1-76)
0
Natriuretic Peptide, Brain
114471-18-0
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
23-31Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest Statement Authors disclose no conflict of interest.