Role of Periodontal Infection, Inflammation and Immunity in Atherosclerosis.
Journal
Current problems in cardiology
ISSN: 1535-6280
Titre abrégé: Curr Probl Cardiol
Pays: Netherlands
ID NLM: 7701802
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
27
05
2020
accepted:
27
05
2020
pubmed:
11
7
2020
medline:
29
7
2021
entrez:
11
7
2020
Statut:
ppublish
Résumé
Inflammation plays a major role in the development and progression of cardiovascular disease (CVD) morbidity and mortality. The well-established relationship between periodontal disease (PD) and CVD may be causal. Left untreated, PD can lead to high systemic inflammation, thus contributing to inflammatory CVD, such as atherosclerosis. Multiple mechanisms have been proposed to elucidate the causal relationship between PD and its contribution to CVD. This review article highlights the current evidence supporting the role of PD in the development and progression of atherosclerosis. After creating a list of relevant medical subject heading (MeSH) terms, a systematic search within PubMed in English for each MeSH term between 2000 and 2019 was used to generate evidence for this review article. There is overwhelming evidence in the current literature that supports an association between PD and CVD that is independent of known CVD risk factors. However, the supporting evidence that PD directly causes CVD in humans continues to remain elusive. Multiple biologically plausible mechanisms have been proposed and investigated, yet most studies are limited to mouse models and in vitro cell cultures. Additional studies testing the various proposed mechanisms in longitudinal human studies are required to provide deeper insight into the mechanistic link between these 2 related diseases.
Sections du résumé
BACKGROUND
BACKGROUND
Inflammation plays a major role in the development and progression of cardiovascular disease (CVD) morbidity and mortality. The well-established relationship between periodontal disease (PD) and CVD may be causal. Left untreated, PD can lead to high systemic inflammation, thus contributing to inflammatory CVD, such as atherosclerosis. Multiple mechanisms have been proposed to elucidate the causal relationship between PD and its contribution to CVD.
OBJECTIVE
OBJECTIVE
This review article highlights the current evidence supporting the role of PD in the development and progression of atherosclerosis.
METHODS
METHODS
After creating a list of relevant medical subject heading (MeSH) terms, a systematic search within PubMed in English for each MeSH term between 2000 and 2019 was used to generate evidence for this review article.
CONCLUSION
CONCLUSIONS
There is overwhelming evidence in the current literature that supports an association between PD and CVD that is independent of known CVD risk factors. However, the supporting evidence that PD directly causes CVD in humans continues to remain elusive. Multiple biologically plausible mechanisms have been proposed and investigated, yet most studies are limited to mouse models and in vitro cell cultures. Additional studies testing the various proposed mechanisms in longitudinal human studies are required to provide deeper insight into the mechanistic link between these 2 related diseases.
Identifiants
pubmed: 32646544
pii: S0146-2806(20)30115-8
doi: 10.1016/j.cpcardiol.2020.100638
pmc: PMC8761259
mid: NIHMS1610105
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100638Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL076801
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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