Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance.
atherosclerosis
cardiovascular disease
familial hypercholesterolemia
lipidomics
low density lipoprotein receptor
low density lipoprotein-cholesterol
very low density lipoprotein
Journal
Journal of lipid research
ISSN: 1539-7262
Titre abrégé: J Lipid Res
Pays: United States
ID NLM: 0376606
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
06
05
2020
revised:
01
07
2020
pubmed:
11
7
2020
medline:
5
10
2021
entrez:
11
7
2020
Statut:
ppublish
Résumé
Angiopoietin-like protein (ANGPTL)3 regulates plasma lipids by inhibiting LPL and endothelial lipase (EL). ANGPTL3 inactivation lowers LDL-C independently of the classical LDLR-mediated pathway and represents a promising therapeutic approach for individuals with homozygous familial hypercholesterolemia due to
Identifiants
pubmed: 32646941
pii: S0022-2275(20)43692-2
doi: 10.1194/jlr.RA120000888
pmc: PMC7469887
doi:
Substances chimiques
ANGPTL3 protein, human
0
Angiopoietin-Like Protein 3
0
Angiopoietin-like Proteins
0
Angptl3 protein, mouse
0
Cholesterol, LDL
0
Cholesterol, VLDL
0
Receptors, LDL
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1271-1286Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL020948
Pays : United States
Informations de copyright
Copyright © 2020 Adam et al. Published by The American Society for Biochemistry and Molecular Biology, Inc.
Déclaration de conflit d'intérêts
Conflict of interest—R.C.A., I.J.M., C.A.A-B., L.M.S., J.S.L., P.B., S.C.H., H.I.K., C.V.H., G.D.Y., A.J.M., J.G., M.W.S. and V.G. are or were employees and stockholders at Regeneron Pharmaceuticals while engaged in this study. All other authors declare that they have no conflicts of interest with the contents of this article.
Références
Genome Biol. 2014;15(12):550
pubmed: 25516281
J Clin Invest. 2003 Feb;111(3):347-55
pubmed: 12569160
Nat Biotechnol. 2003 Jun;21(6):652-9
pubmed: 12730667
J Lipid Res. 2015 Jul;56(7):1308-17
pubmed: 25964512
Circulation. 2019 Aug 6;140(6):470-486
pubmed: 31242752
Mol Metab. 2017 Oct;6(10):1137-1149
pubmed: 29031715
Biochim Biophys Acta. 1978 Dec 22;531(3):344-51
pubmed: 216396
N Engl J Med. 2017 Jul 20;377(3):296-297
pubmed: 28723334
J Biol Chem. 2003 Sep 5;278(36):34331-8
pubmed: 12810721
Heart. 2019 Jul;105(13):975-981
pubmed: 30988003
J Lipid Res. 2017 Jun;58(6):1166-1173
pubmed: 28413163
Nat Rev Cardiol. 2016 Feb;13(2):74-5
pubmed: 26763537
Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):229-34
pubmed: 12509515
J Clin Invest. 2009 Nov;119(11):3236-45
pubmed: 19805913
Biochemistry. 1994 Feb 8;33(5):1172-80
pubmed: 7509190
Nat Genet. 2015 Mar;47(3):284-90
pubmed: 25642633
Arterioscler Thromb Vasc Biol. 2019 Jan;39(1):63-72
pubmed: 30580564
Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16109-14
pubmed: 24043787
J Clin Invest. 2009 Jan;119(1):70-9
pubmed: 19075393
Proc Natl Acad Sci U S A. 1989 Aug;86(15):5810-4
pubmed: 2762297
Proc Natl Acad Sci U S A. 1992 May 15;89(10):4471-5
pubmed: 1584779
J Biomed Res. 2014 May;28(3):178-93
pubmed: 25013401
J Lipid Res. 2005 Dec;46(12):2586-94
pubmed: 16199802
J Lipid Res. 2005 Jun;46(6):1097-102
pubmed: 15772433
J Clin Endocrinol Metab. 2012 Jul;97(7):E1266-75
pubmed: 22659251
J Clin Invest. 1999 Mar;103(6):907-14
pubmed: 10079112
N Engl J Med. 2017 Jul 20;377(3):211-221
pubmed: 28538136
J Lipid Res. 2015 Jul;56(7):1296-307
pubmed: 25954050
Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5153-8
pubmed: 24706856
J Biol Chem. 2009 May 15;284(20):13735-45
pubmed: 19318355
Comp Biochem Physiol B. 1982;71(2):265-9
pubmed: 7060347
J Biol Chem. 2002 Sep 13;277(37):33742-8
pubmed: 12097324
Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):665-674
pubmed: 30816800
Nat Genet. 1999 Apr;21(4):424-8
pubmed: 10192396
J Am Coll Cardiol. 2017 Apr 25;69(16):2054-2063
pubmed: 28385496
Circulation. 2003 Oct 28;108(17):2121-6
pubmed: 14517167
N Engl J Med. 2014 Jul 3;371(1):22-31
pubmed: 24941081
J Clin Invest. 2016 Aug 1;126(8):2855-66
pubmed: 27400128
J Proteomics. 2015 Sep 8;127(Pt B):275-88
pubmed: 25668325
Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2065-74
pubmed: 23846497
Sci Rep. 2017 Oct 2;7(1):12485
pubmed: 28970555
Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11630-5
pubmed: 26305978
N Engl J Med. 2014 Jul 3;371(1):32-41
pubmed: 24941082
Circ Res. 2004 Jun 25;94(12):1554-61
pubmed: 15117821
J Biol Chem. 1995 Dec 1;270(48):28767-76
pubmed: 7499399
N Engl J Med. 1978 Nov 30;299(22):1232-6
pubmed: 213711
Circ J. 2010 Nov;74(11):2263-70
pubmed: 20962428
Nat Rev Genet. 2009 Feb;10(2):109-21
pubmed: 19139765
N Engl J Med. 2010 Dec 2;363(23):2220-7
pubmed: 20942659
Arterioscler Thromb Vasc Biol. 2007 Feb;27(2):366-72
pubmed: 17110602
Endocrinology. 2017 May 1;158(5):1252-1259
pubmed: 28204173
Curr Opin Lipidol. 2019 Jun;30(3):205-211
pubmed: 30893111
J Biol Chem. 1975 Sep 10;250(17):6756-61
pubmed: 1158882
Nucleic Acids Res. 2012 Jul;40(13):6135-43
pubmed: 22467214
J Lipid Res. 2008 Jul;49(7):1553-61
pubmed: 18367731
J Proteome Res. 2012 Apr 6;11(4):2521-32
pubmed: 22364559
J Lipid Res. 2002 Jun;43(6):921-9
pubmed: 12032167
J Lipid Res. 2020 Mar;61(3):365-375
pubmed: 31843957
N Engl J Med. 2017 Jul 20;377(3):222-232
pubmed: 28538111
N Engl J Med. 2016 Mar 24;374(12):1123-33
pubmed: 26933753
J Biol Chem. 2009 Mar 6;284(10):6093-100
pubmed: 19136670
Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5147-52
pubmed: 24706858
J Clin Invest. 2009 Apr;119(4):1042-50
pubmed: 19287092
J Lipid Res. 1993 Aug;34(8):1367-83
pubmed: 8409768