Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice.
EC-SOD
carboxypeptidase
cardiac hypertrophy
cardiac remodeling
cathepsin A
extracellular matrix protein
extracellular superoxide dismutase
fibrosis
heart disease
heart failure
left ventricular dysfunction
oxidative stress
oxygen radicals
secretome
superoxide dismutase (SOD)
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
04 09 2020
04 09 2020
Historique:
received:
20
03
2020
revised:
29
06
2020
pubmed:
11
7
2020
medline:
28
1
2021
entrez:
11
7
2020
Statut:
ppublish
Résumé
In the heart, the serine carboxypeptidase cathepsin A (CatA) is distributed between lysosomes and the extracellular matrix (ECM). CatA-mediated degradation of extracellular peptides may contribute to ECM remodeling and left ventricular (LV) dysfunction. Here, we aimed to evaluate the effects of CatA overexpression on LV remodeling. A proteomic analysis of the secretome of adult mouse cardiac fibroblasts upon digestion by CatA identified the extracellular antioxidant enzyme superoxide dismutase (EC-SOD) as a novel substrate of CatA, which decreased EC-SOD abundance 5-fold.
Identifiants
pubmed: 32647007
pii: S0021-9258(17)49977-7
doi: 10.1074/jbc.RA120.013488
pmc: PMC7476717
doi:
Substances chimiques
Sod3 protein, mouse
EC 1.15.1.1
Superoxide Dismutase
EC 1.15.1.1
Cathepsin A
EC 3.4.16.5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
12605-12617Subventions
Organisme : Medical Research Council
ID : MC_UP_1502/3
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/16/14/32397
Pays : United Kingdom
Informations de copyright
© 2020 Hohl et al.
Déclaration de conflit d'intérêts
Conflict of interest—Sven Ruf, Thomas Hübschle, and Thorsten Sadowski are employees of Sanofi-Aventis Deutschland GmbH. The other authors have not conflicts of interest.
Références
Circulation. 2008 Apr 15;117(15):1973-81
pubmed: 18391110
J Biol Chem. 2001 Jan 12;276(2):944-51
pubmed: 11016923
J Biol Chem. 2004 Apr 2;279(14):13705-10
pubmed: 14736885
Mol Cell Biochem. 2008 Jan;307(1-2):159-67
pubmed: 17849172
EMBO J. 1991 Dec;10(13):4041-8
pubmed: 1756715
Hypertension. 2002 May;39(5):976-81
pubmed: 12019279
Cell Mol Life Sci. 1999 Dec;56(11-12):894-907
pubmed: 11212324
Cell Metab. 2015 Sep 1;22(3):472-84
pubmed: 26256392
J Transl Med. 2016 May 31;14(1):153
pubmed: 27246731
Cardiovasc Res. 2016 Jun 1;110(3):371-80
pubmed: 27032673
Eur Heart J. 2013 Sep;34(36):2839-49
pubmed: 22833515
Sci Rep. 2017 Sep 7;7(1):10801
pubmed: 28883544
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2700-5
pubmed: 12586861
Circ Res. 2009 Dec 4;105(12):1164-76
pubmed: 19959782
J Med Chem. 2012 Sep 13;55(17):7636-49
pubmed: 22861813
J Clin Invest. 2017 May 1;127(5):1600-1612
pubmed: 28459429
Histochem J. 1996 Apr;28(4):229-45
pubmed: 8762055
Mol Cell Proteomics. 2010 Mar;9(3):497-509
pubmed: 20037178
Hypertension. 2008 Jan;51(1):19-25
pubmed: 17998475
Basic Res Cardiol. 2011 Sep;106(5):735-47
pubmed: 21598086
JACC Basic Transl Sci. 2019 Jun 24;4(3):332-344
pubmed: 31312757
J Proteome Res. 2016 Sep 2;15(9):3188-95
pubmed: 27432266
Fibrogenesis Tissue Repair. 2012 Sep 03;5(1):15
pubmed: 22943504
J Biol Chem. 1990 Jul 5;265(19):11265-72
pubmed: 1694176
Biochem Biophys Res Commun. 2001 Jun 22;284(4):966-71
pubmed: 11409888
Front Mol Biosci. 2016 Oct 25;3:68
pubmed: 27826550
Stem Cells. 2014 Sep;32(9):2480-91
pubmed: 24806289
Free Radic Biol Med. 2008 Apr 1;44(7):1305-13
pubmed: 18206658
Nucleic Acids Res. 2019 Jan 8;47(D1):D442-D450
pubmed: 30395289
Circ Res. 2013 Oct 25;113(10):1138-47
pubmed: 24006456
J Biol Chem. 2004 May 21;279(21):22152-7
pubmed: 15044467
J Mol Cell Cardiol. 2009 Nov;47(5):730-42
pubmed: 19695260
Circulation. 2012 Mar 27;125(12):1551-62
pubmed: 22451605
Free Radic Biol Med. 2011 May 1;50(9):1075-80
pubmed: 21334435
Circulation. 2012 Feb 14;125(6):789-802
pubmed: 22261194
Heart Fail Rev. 2012 May;17(3):395-409
pubmed: 21739365
Methods Enzymol. 2010;476:285-94
pubmed: 20691872
Circulation. 2016 Sep 13;134(11):817-32
pubmed: 27559042