Monitoring indices of bone inflammatory activity of the jaw using SPECT bone scintigraphy: a study of ARONJ patients.
Aged
Aged, 80 and over
Bisphosphonate-Associated Osteonecrosis of the Jaw
/ complications
Bone Density Conservation Agents
/ adverse effects
Diphosphonates
/ adverse effects
Female
Humans
Jaw
/ diagnostic imaging
Male
Middle Aged
Osteomyelitis
/ diagnosis
Pilot Projects
Prognosis
Retrospective Studies
Software
Tomography, Emission-Computed, Single-Photon
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
09 07 2020
09 07 2020
Historique:
received:
30
10
2019
accepted:
24
06
2020
entrez:
11
7
2020
pubmed:
11
7
2020
medline:
22
12
2020
Statut:
epublish
Résumé
Development of quantitative analysis software has enabled application of several standardised uptake values (SUV) for bone analysis in single photon emission computed tomography (SPECT). The present retrospective study aimed to develop a reliable method of monitoring bone inflammatory activity in antiresorptive agent-related osteonecrosis of the jaw (ARONJ) using SPECT quantitative analysis software. Fifteen ARONJ patients underwent SPECT before and after anti-inflammatory therapy. We calculated the mean maximum SUV (SUVmax) of the bilateral cranial bones using quantitative analysis software and used this as the control [C]. We attempted to adjust the SUVmax of the lesion [L] as follows: adjusted SUVmax (aSUVmax) = [L] - [C]. The optimum threshold to calculate the metabolic bone volume (MBV) (cm
Identifiants
pubmed: 32647190
doi: 10.1038/s41598-020-68428-x
pii: 10.1038/s41598-020-68428-x
pmc: PMC7347656
doi:
Substances chimiques
Bone Density Conservation Agents
0
Diphosphonates
0
Types de publication
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11385Références
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