Recapitulating atherogenic flow disturbances and vascular inflammation in a perfusable 3D stenosis model.
Atherosclerosis
/ pathology
Blood Vessels
/ pathology
Constriction, Pathologic
Drug Monitoring
Endothelial Cells
/ pathology
Hemorheology
Imaging, Three-Dimensional
Immunologic Factors
/ pharmacology
Inflammation
/ pathology
Models, Cardiovascular
Perfusion
Phenotype
Thrombosis
/ pathology
Tissue Engineering
Journal
Biofabrication
ISSN: 1758-5090
Titre abrégé: Biofabrication
Pays: England
ID NLM: 101521964
Informations de publication
Date de publication:
10 08 2020
10 08 2020
Historique:
pubmed:
11
7
2020
medline:
9
6
2021
entrez:
11
7
2020
Statut:
epublish
Résumé
Blood vessel narrowing and arterial occlusion are pathological hallmarks of atherosclerosis, which involves a complex interplay of perturbed hemodynamics, endothelial dysfunction and inflammatory cascade. Herein, we report a novel circular microfluidic stenosis model that recapitulates atherogenic flow-mediated endothelial dysfunction and blood-endothelial cell (EC) interactions in vitro. 2D and 3D stenosis microchannels with different constriction geometries were fabricated using 3D printing to study flow disturbances under varying severity of occlusion and wall shear stresses (100 to 2000 dynecm
Identifiants
pubmed: 32650321
doi: 10.1088/1758-5090/aba501
doi:
Substances chimiques
Immunologic Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM