Anti-Biofilm Activity of the Fungal Phytotoxin Sphaeropsidin A Against Clinical Isolates of Antibiotic-Resistant Bacteria.
antibiotic-resistance
biofilm
biological activity
epi-epoformin
fungal secondary metabolites
sphaeropsidin A
toxins
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
08 07 2020
08 07 2020
Historique:
received:
27
05
2020
revised:
02
07
2020
accepted:
06
07
2020
entrez:
12
7
2020
pubmed:
12
7
2020
medline:
3
3
2021
Statut:
epublish
Résumé
Many pathogens involved in human infection have rapidly increased their antibiotic resistance, reducing the effectiveness of therapies in recent decades. Most of them can form biofilms and effective drugs are not available to treat these formations. Natural products could represent an efficient solution in discovering and developing new drugs to overcome antimicrobial resistance and treat biofilm-related infections. In this study, 20 secondary metabolites produced by pathogenic fungi of forest plants and belonging to diverse classes of naturally occurring compounds were evaluated for the first time against clinical isolates of antibiotic-resistant Gram-negative and Gram-positive bacteria.
Identifiants
pubmed: 32650496
pii: toxins12070444
doi: 10.3390/toxins12070444
pmc: PMC7404997
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bridged Bicyclo Compounds, Heterocyclic
0
Diterpenes
0
epiepoformin
0
sphaeropsidin A
9F59Q9OS1I
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Compagnia di San Paolo
ID : E62F16001250003
Pays : International
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