Anomalous behavior of mannitol hemihydrate: Implications on sucrose crystallization in colyophilized systems.

Crystallization Freeze Drying Mannitol Sucrose Water
Dehydration Freeze-drying Mannitol Mannitol hemihydrate Moisture content Rubber stopper Smith-Topley effect Sucrose X-ray diffractometry

Journal

International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127

Informations de publication

Date de publication:
25 Sep 2020
Historique:
received: 06 04 2020
revised: 07 06 2020
accepted: 06 07 2020
pubmed: 13 7 2020
medline: 22 6 2021
entrez: 13 7 2020
Statut: ppublish

Résumé

When solutions containing mannitol and sucrose are freeze-dried, depending on the processing conditions and the formulation composition, mannitol can crystallize in the anhydrous form, as mannitol hemihydrate (MHH; C

Identifiants

DOI: 10.1016/j.ijpharm.2020.119629 PMID: 32653598
pubmed: 32653598
pii: S0378-5173(20)30613-X
doi: 10.1016/j.ijpharm.2020.119629
pii:
doi:

Substances chimiques

Water 059QF0KO0R
Mannitol 3OWL53L36A
Sucrose 57-50-1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

119629

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Seema Thakral (S)

Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, United States; Characterization Facility, University of Minnesota, Minneapolis, MN 55455, United States.

Jayesh Sonje (J)

Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, United States.

Raj Suryanarayanan (R)

Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, United States. Electronic address: surya001@umn.edu.

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Cristallisation › Anomalous behavior of mannitol hemihydrate:...
questionsmedicales.fr › Techniques d'investigation › Conservation biologique › Cryoconservation › Lyophilisation › Anomalous behavior of mannitol hemihydrate:...
questionsmedicales.fr › Glucides › Polyols › Mannitol › Anomalous behavior of mannitol hemihydrate:...
questionsmedicales.fr › Glucides › Sucres › Diholoside › Saccharose › Anomalous behavior of mannitol hemihydrate:...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Eau › Anomalous behavior of mannitol hemihydrate:...