LPAR2 receptor activation attenuates radiation-induced disruption of apical junctional complexes and mucosal barrier dysfunction in mouse colon.
Adherens Junctions
/ drug effects
Animals
Caco-2 Cells
Cell Line
Colon
/ drug effects
Humans
Intercellular Junctions
/ drug effects
Intestinal Mucosa
/ drug effects
Lysophospholipids
/ pharmacology
Mice, Knockout
Permeability
/ drug effects
Radiation, Ionizing
Receptors, Lysophosphatidic Acid
/ genetics
Tight Junction Proteins
/ genetics
Tight Junctions
/ drug effects
endotoxemia
intestine
irradiation
lysophosphatidic acid
tight junction
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
09
03
2020
revised:
28
05
2020
accepted:
15
06
2020
pubmed:
13
7
2020
medline:
23
3
2021
entrez:
13
7
2020
Statut:
ppublish
Résumé
The tight junction (TJ) and barrier function of colonic epithelium is highly sensitive to ionizing radiation. We evaluated the effect of lysophosphatidic acid (LPA) and its analog, Radioprotein-1, on γ-radiation-induced colonic epithelial barrier dysfunction using Caco-2 and m-IC
Identifiants
pubmed: 32654268
doi: 10.1096/fj.202000544R
pmc: PMC7725959
mid: NIHMS1620002
doi:
Substances chimiques
Lysophospholipids
0
Receptors, Lysophosphatidic Acid
0
Tight Junction Proteins
0
lysophosphatidic acid
PG6M3969SG
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
11641-11657Subventions
Organisme : HHS | NIH | National Cancer Institute (NCI)
ID : CA013621
Organisme : NIDDK NIH HHS
ID : R01 DK055532
Pays : United States
Organisme : NIDDK NIH HHS
ID : R56 DK055532
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA012307
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI107331
Pays : United States
Informations de copyright
© 2020 Federation of American Societies for Experimental Biology.
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