High-resolution crystal structures of the botulinum neurotoxin binding domains from subtypes A5 and A6.
Clostridium botulinum
X-ray crystallography
binding domain structure
botulinum neurotoxin
subtypes
Journal
FEBS open bio
ISSN: 2211-5463
Titre abrégé: FEBS Open Bio
Pays: England
ID NLM: 101580716
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
18
06
2020
revised:
07
07
2020
accepted:
08
07
2020
pubmed:
13
7
2020
medline:
5
11
2021
entrez:
13
7
2020
Statut:
ppublish
Résumé
Clostridium botulinum neurotoxins (BoNTs) cause flaccid paralysis through inhibition of acetylcholine release from motor neurons; however, at tiny doses, this property is exploited for use as a therapeutic. Each member of the BoNT family of proteins consists of three distinct domains: a binding domain that targets neuronal cell membranes (H
Identifiants
pubmed: 32654405
doi: 10.1002/2211-5463.12931
pmc: PMC7396429
doi:
Substances chimiques
Botulinum Toxins, Type A
EC 3.4.24.69
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1474-1481Informations de copyright
© 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.
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