Shorter Diagnostic Delay in Polish Adult Patients With Common Variable Immunodeficiency and Symptom Onset After 1999.
adults
common variable immunodeficiency
diagnostic delay
epidemiology
hypogammaglobulinemia
primary antibody deficiency
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
03
2020
accepted:
27
04
2020
entrez:
14
7
2020
pubmed:
14
7
2020
medline:
7
4
2021
Statut:
epublish
Résumé
Common variable immunodeficiency (CVID) is the most clinically significant primary antibody immunodeficiency recognized in adulthood. Previously published data have shown an average diagnostic delay of 10 years for Polish adult patients with CVID. In the current study, we aimed to analyze the current diagnostic delay of adult patients with CVID in Poland. To this end, we identified patients from four immunological centers specialized in the care of adult patients with primary immunodeficiencies (PID). Demographic and clinical data of patients were collected using an internet database. We identified 103 adult patients (F:M 44.7%:55.3%) in Poland with CVID. The median age at onset of symptoms was 24 (0-66), 33 (4-70) at diagnosis, and 37 (18-73) years at the time of analysis. The median diagnostic delay for the entire study population was 6 (0-57) years. However, this delay was higher in patients with symptom onset before the year 2000 than after the year 1999 [15 (0-57) vs. 3 (0-19) years;
Identifiants
pubmed: 32655544
doi: 10.3389/fimmu.2020.00982
pmc: PMC7326034
doi:
Types de publication
Comparative Study
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
982Informations de copyright
Copyright © 2020 Ziętkiewicz, Więsik-Szewczyk, Matyja-Bednarczyk, Napiórkowska-Baran, Zdrojewski and Jahnz-Różyk.
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