A novel distal convoluted tubule-specific Cre-recombinase driven by the NaCl cotransporter gene.

Animals Estrogen Antagonists / pharmacology Gene Expression Regulation / drug effects Kidney Tubules, Distal / enzymology Mice Recombinases / genetics Sodium Chloride Symporters / genetics Solute Carrier Family 12, Member 3 / genetics Tamoxifen / pharmacology
Cre recombinase NaCl cotransporter distal convoluted tubule potassium sodium

Journal

American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990

Informations de publication

Date de publication:
01 09 2020
Historique:
pubmed: 14 7 2020
medline: 28 11 2020
entrez: 14 7 2020
Statut: ppublish

Résumé

Cre-lox technology has revolutionized research in renal physiology by allowing site-specific genetic recombination in individual nephron segments. The distal convoluted tubule (DCT), consisting of distinct early (DCT1) and late (DCT2) segments, plays a central role in Na

Identifiants

DOI: 10.1152/ajprenal.00101.2020 PMID: 32657158 PMC: PMC7509282
pubmed: 32657158
doi: 10.1152/ajprenal.00101.2020
pmc: PMC7509282
doi:

Substances chimiques

Estrogen Antagonists 0
Recombinases 0
Slc12a3 protein, mouse 0
Sodium Chloride Symporters 0
Solute Carrier Family 12, Member 3 0
Tamoxifen 094ZI81Y45

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

F423-F435

Subventions

Organisme : NIDDK NIH HHS
ID : K01 DK120790
Pays : United States
Organisme : HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ID : DK054196
Pays : International
Organisme : NIDDK NIH HHS
ID : R01 DK098141
Pays : United States
Organisme : NIDDK NIH HHS
ID : R56 DK117903
Pays : United States
Organisme : U.S. Department of Veterans Affairs (VA)
ID : 1I01BX002228
Pays : International
Organisme : BLRD VA
ID : I01 BX002228
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK054364
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK110792
Pays : United States

Références

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Auteurs

Ryan J Cornelius (RJ)

Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.
ORCID: 0000-0002-1389-1493

Avika Sharma (A)

Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.

Xiao-Tong Su (XT)

Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.
ORCID: 0000-0001-8121-8105

Jin-Jin Guo (JJ)

Department of Stem Cell Biology and Regenerative Medicine, Broad California Institute of Regenerative Medicine Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

Jill A McMahon (JA)

Department of Stem Cell Biology and Regenerative Medicine, Broad California Institute of Regenerative Medicine Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

David H Ellison (DH)

Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.
Veterans Affairs Portland Health Care System, Portland, Oregon.
ORCID: 0000-0003-2915-265X

Andrew P McMahon (AP)

Department of Stem Cell Biology and Regenerative Medicine, Broad California Institute of Regenerative Medicine Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

James A McCormick (JA)

Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A novel distal convoluted tubule-specific...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Antihormones › Antagonistes des oestrogènes › A novel distal convoluted tubule-specific...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › A novel distal convoluted tubule-specific...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Néphrons › Tubules rénaux › Tubules contournés distaux › A novel distal convoluted tubule-specific...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A novel distal convoluted tubule-specific...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Recombinases › A novel distal convoluted tubule-specific...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Symporteurs des ions sodium-chlorure › A novel distal convoluted tubule-specific...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Symporteurs des ions sodium-potassium-chlorure › Membre-3 de la famille-12 des transporteurs de solutés › A novel distal convoluted tubule-specific...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Composés benzylidéniques › Stilbènes › Tamoxifène › A novel distal convoluted tubule-specific...