Effect of renal function on association between uric acid and prognosis in acute ischemic stroke patients with elevated systolic blood pressure.
Uric acid
ischemic stroke
renal function
Journal
Neurological research
ISSN: 1743-1328
Titre abrégé: Neurol Res
Pays: England
ID NLM: 7905298
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
pubmed:
14
7
2020
medline:
21
8
2021
entrez:
14
7
2020
Statut:
ppublish
Résumé
The prognostic value of uric acid in ischemic stroke remains controversial, and it is unclear whether renal function status modifies the prognostic value of uric acid in ischemic stroke patients. A total of 3284 acute ischemic stroke patients from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS) with creatinine and uric acid measurements were included in this analysis. The primary outcome was a composite of death and major disability (modified Rankin Scale score ≥3) at 1 year after stroke. The prognostic value of uric acid in ischemic stroke was appreciably modified by patients' renal function status ( The present study suggests that high serum uric acid concentration is associated with better prognosis in ischemic stroke patients with normal renal function, but not in those with abnormal renal function. The establishment of causality between increased uric acid levels and better stroke prognosis needs more suitably designed randomized clinical trials.
Sections du résumé
BACKGROUND AND AIMS
OBJECTIVE
The prognostic value of uric acid in ischemic stroke remains controversial, and it is unclear whether renal function status modifies the prognostic value of uric acid in ischemic stroke patients.
METHODS
METHODS
A total of 3284 acute ischemic stroke patients from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS) with creatinine and uric acid measurements were included in this analysis. The primary outcome was a composite of death and major disability (modified Rankin Scale score ≥3) at 1 year after stroke.
RESULTS
RESULTS
The prognostic value of uric acid in ischemic stroke was appreciably modified by patients' renal function status (
CONCLUSION
CONCLUSIONS
The present study suggests that high serum uric acid concentration is associated with better prognosis in ischemic stroke patients with normal renal function, but not in those with abnormal renal function. The establishment of causality between increased uric acid levels and better stroke prognosis needs more suitably designed randomized clinical trials.
Identifiants
pubmed: 32657261
doi: 10.1080/01616412.2020.1792688
doi:
Substances chimiques
Biomarkers
0
Uric Acid
268B43MJ25
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM