Immunobiology and structural biology of AIM2 inflammasome.
AIM2 inflammasome
DNA binding
Death domain
HIN domain
Helical filament
Nucleated polymerization
PYD
Journal
Molecular aspects of medicine
ISSN: 1872-9452
Titre abrégé: Mol Aspects Med
Pays: England
ID NLM: 7603128
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
14
04
2020
revised:
29
05
2020
accepted:
05
06
2020
pubmed:
15
7
2020
medline:
25
9
2021
entrez:
15
7
2020
Statut:
ppublish
Résumé
Absent in melanoma 2 (AIM2) is a cytoplasmic sensor that upon recognizing double-stranded DNA assembles with apoptosis-associated speck-like protein containing a CARD (ASC) and procaspase-1 to form the multi-protein complex AIM2 inflammasome. Double-stranded DNA from bacterial, viral, or host cellular origins triggers AIM2 inflammasome assembly and activation, ultimately resulting in secretion of proinflammatory cytokines and pyroptotic cell death in order to eliminate microbial infection. Many pathogens therefore evade or suppress AIM2 inflammasome to establish infection. On the other hand, AIM2 activation is tightly controlled by multiple cellular factors to prevent autoinflammation. Extensive structural studies have captured the molecular details of multiple steps in AIM2 inflammasome assembly. The structures collectively revealed a nucleated polymerization mechanism that not only pervades each step of AIM2 inflammasome assembly, but also underlies assembly of other inflammasomes and complexes in immune signaling. In this article, we briefly review the identification of AIM2 as a cytoplasmic DNA sensor, summarize the importance of AIM2 inflammasome in infections and diseases, and discuss the molecular mechanisms of AIM2 assembly, activation, and regulation using recent cellular, biochemical, and structural results.
Identifiants
pubmed: 32660715
pii: S0098-2997(20)30051-0
doi: 10.1016/j.mam.2020.100869
pmc: PMC7958902
mid: NIHMS1611195
pii:
doi:
Substances chimiques
AIM2 protein, human
0
DNA-Binding Proteins
0
Inflammasomes
0
Caspase 1
EC 3.4.22.36
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100869Subventions
Organisme : NIAID NIH HHS
ID : R01 AI146330
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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