Aberrant Fiber Coherence of Amygdala-Accumbens-Pallidum Pathway Is Associated With Disorganized Nigrostriatal-Nigropallidal Pathway in Parkinson's Disease.
Parkinson's disease
diffusion tensor imaging
limbic system
motor symptoms
neurite orientation dispersion and density imaging
Journal
Journal of magnetic resonance imaging : JMRI
ISSN: 1522-2586
Titre abrégé: J Magn Reson Imaging
Pays: United States
ID NLM: 9105850
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
12
04
2020
revised:
15
06
2020
accepted:
16
06
2020
pubmed:
15
7
2020
medline:
15
5
2021
entrez:
15
7
2020
Statut:
ppublish
Résumé
Motor disturbances in Parkinson's disease (PD) mainly result from the degeneration of classic motor pathways. Given that the specific limbic pathway participates in movements, it is reasonable to consider that limbic pathway have the pathologic potential of motor disturbance in PD. To explore the white matter changes of limbic and motor pathways and their relations in PD patients. Prospective. 39 PD patients and 55 normal controls. Sagittal 3D T Probabilistic tractography was used to reconstruct the motor pathways (nigrostriatal-nigropallidal and basal ganglia-motor cortex pathways) and limbic pathway (amygdala-accumbens-pallidum pathway). White matter alterations of these pathways were evaluated by fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD), neurite density (NDI), and orientation dispersion (ODI). Clinical assessment was conducted by a neurologist. Group comparisons were performed using unpaired t-tests. Pearson or Spearman correlation was used to explore the relationships between variables. Compared with normal controls, PD patients showed decreased ODI as well as increased MD and AD in the bilateral nigrostriatal-nigropallidal pathway (P < 0.05), decreased FA in left basal ganglia-motor cortex pathway (P < 0.05), and decreased ODI in left limbic pathway (P < 0.05). MD and AD in the left nigrostriatal-nigropallidal pathway was negatively correlated with FA in left basal ganglia-motor cortex pathway (r = -0.597, P < 0.05 and r = -0.433, P < 0.05, respectively). MD in the left nigrostriatal-nigropallidal pathway was significantly correlated with ODI in the left limbic pathway (r = -0.404, P < 0.05). ODI was associated with AD within each hemisphere of the nigrostriatal-nigropallidal pathway (r = -0.591, P < 0.05 for left; r = -0.589, P < 0.05 for right). The relationship between the degenerated motor pathways and aberrant limbic pathway suggest the existence of neuronal modulation between motor and limbic pathways, providing novel evidence of the neuromechanism for motor disruption in PD patients. 2 TECHNICAL EFFICACY STAGE: 1 J. MAGN. RESON. IMAGING 2020;52:1799-1808.
Sections du résumé
BACKGROUND
Motor disturbances in Parkinson's disease (PD) mainly result from the degeneration of classic motor pathways. Given that the specific limbic pathway participates in movements, it is reasonable to consider that limbic pathway have the pathologic potential of motor disturbance in PD.
PURPOSE
To explore the white matter changes of limbic and motor pathways and their relations in PD patients.
STUDY TYPE
Prospective.
POPULATION
39 PD patients and 55 normal controls.
SEQUENCE
Sagittal 3D T
ASSESSMENT
Probabilistic tractography was used to reconstruct the motor pathways (nigrostriatal-nigropallidal and basal ganglia-motor cortex pathways) and limbic pathway (amygdala-accumbens-pallidum pathway). White matter alterations of these pathways were evaluated by fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD), neurite density (NDI), and orientation dispersion (ODI). Clinical assessment was conducted by a neurologist.
STATISTICAL TESTS
Group comparisons were performed using unpaired t-tests. Pearson or Spearman correlation was used to explore the relationships between variables.
RESULTS
Compared with normal controls, PD patients showed decreased ODI as well as increased MD and AD in the bilateral nigrostriatal-nigropallidal pathway (P < 0.05), decreased FA in left basal ganglia-motor cortex pathway (P < 0.05), and decreased ODI in left limbic pathway (P < 0.05). MD and AD in the left nigrostriatal-nigropallidal pathway was negatively correlated with FA in left basal ganglia-motor cortex pathway (r = -0.597, P < 0.05 and r = -0.433, P < 0.05, respectively). MD in the left nigrostriatal-nigropallidal pathway was significantly correlated with ODI in the left limbic pathway (r = -0.404, P < 0.05). ODI was associated with AD within each hemisphere of the nigrostriatal-nigropallidal pathway (r = -0.591, P < 0.05 for left; r = -0.589, P < 0.05 for right).
DATA CONCLUSION
The relationship between the degenerated motor pathways and aberrant limbic pathway suggest the existence of neuronal modulation between motor and limbic pathways, providing novel evidence of the neuromechanism for motor disruption in PD patients.
LEVEL OF EVIDENCE
2 TECHNICAL EFFICACY STAGE: 1 J. MAGN. RESON. IMAGING 2020;52:1799-1808.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1799-1808Subventions
Organisme : the 13th Five-year Plan for National Key Research and Development Program of China
ID : 2016YFC1306600
Pays : International
Organisme : the National Natural Science Foundation of China
ID : 81571654
Pays : International
Organisme : the National Natural Science Foundation of China
ID : 81701647
Pays : International
Organisme : the National Natural Science Foundation of China
ID : 81771820
Pays : International
Organisme : the National Natural Science Foundation of China
ID : 81971577
Pays : International
Organisme : the Project funded by China Postdoctoral Science Foundation
ID : 2019M662082
Pays : International
Informations de copyright
© 2020 International Society for Magnetic Resonance in Medicine.
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