Insight into antimicrobial activity of substituted phenylcarbamoyloxypiperazinylpropanols.
Antibacterial
Antibiofilm activity
Antimycobacterial
Antiproliferative effect
Carbamate
Piperazine
Synergy
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
02
04
2020
revised:
20
05
2020
accepted:
26
06
2020
pubmed:
15
7
2020
medline:
9
3
2021
entrez:
15
7
2020
Statut:
ppublish
Résumé
3-[4-(Substituted)phenyl-/4-(diphenylmethyl)phenylpiperazin-1-yl]-2-hydroxypropyl-1-[(substituted)phenyl]carbamates and their salts with hydrochloric acid were synthesized, characterized, and tested in vitro against Staphylococcus aureus ATCC 29213 and Enterococcus faecalis ATCC 29212 as reference and quality control strains, against three methicillin-resistant isolates of S. aureus, and three isolates of vancomycin-resistant E. faecalis. All the compounds were evaluated against Mycobacterium tuberculosis H
Identifiants
pubmed: 32663668
pii: S0045-2068(20)31357-2
doi: 10.1016/j.bioorg.2020.104060
pii:
doi:
Substances chimiques
Anti-Infective Agents
0
Carbamates
0
Piperazines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104060Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.