Compulsive alcohol consumption is regulated by dorsal striatum fast-spiking interneurons.
Journal
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
ISSN: 1740-634X
Titre abrégé: Neuropsychopharmacology
Pays: England
ID NLM: 8904907
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
23
04
2020
accepted:
08
07
2020
revised:
22
06
2020
pubmed:
15
7
2020
medline:
24
6
2021
entrez:
15
7
2020
Statut:
ppublish
Résumé
Compulsive alcohol consumption is a core, treatment-resistant feature of alcohol use disorder. The dorsomedial and dorsolateral striatum support goal-directed and habitual action strategies, respectively. How ethanol targets dorsolateral striatum to drive compulsive consumption is poorly understood. Parvalbumin-expressing striatal fast-spiking interneurons comprise ~1% of the total neuronal striatal population, are enriched dorsolaterally and are functionally modulated by ethanol. To test whether fast-spiking interneurons are necessary for the development of compulsive ethanol consumption, we selectively ablated these neurons in adult male and female C57BL/6 J mice undergoing a voluntary chronic intermittent ethanol consumption paradigm followed by a compulsive ethanol drinking assay. Fast-spiking interneuron ablation curtailed the development of organized ethanol lick sequence behavior, reduced ethanol consumption, and abrogated compulsive consumption of ethanol with the added bitterant quinine. In contrast, fast-spiking interneuron ablation did not affect any index of water or sucrose consumption. These data causally implicate the minority striatal fast-spiking interneuron population as a key component of compulsive ethanol consumption.
Identifiants
pubmed: 32663841
doi: 10.1038/s41386-020-0766-0
pii: 10.1038/s41386-020-0766-0
pmc: PMC7852608
doi:
Substances chimiques
Parvalbumins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
351-359Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA024845
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA028070
Pays : United States
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