Srebp-1c/Fgf21/Pgc-1α Axis Regulated by Leptin Signaling in Adipocytes-Possible Mechanism of Caloric Restriction-Associated Metabolic Remodeling of White Adipose Tissue.
3T3-L1 Cells
Adipocytes
/ metabolism
Adipose Tissue, White
/ metabolism
Animals
Caloric Restriction
/ methods
Fatty Acids
/ metabolism
Fibroblast Growth Factors
/ metabolism
Leptin
/ metabolism
Lipogenesis
Mice
Mice, Inbred C57BL
Mice, Knockout
Mitochondria
/ metabolism
Organelle Biogenesis
Sterol Regulatory Element Binding Protein 1
/ metabolism
Transcription Factors
/ metabolism
Up-Regulation
adipocyte
caloric restriction
fatty acid biosynthesis
mitochondrial biogenesis
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
10 Jul 2020
10 Jul 2020
Historique:
received:
06
06
2020
revised:
04
07
2020
accepted:
08
07
2020
entrez:
16
7
2020
pubmed:
16
7
2020
medline:
9
3
2021
Statut:
epublish
Résumé
Caloric restriction (CR) improves whole body metabolism, suppresses age-related pathophysiology, and extends lifespan in rodents. Metabolic remodeling, including fatty acid (FA) biosynthesis and mitochondrial biogenesis, in white adipose tissue (WAT) plays an important role in the beneficial effects of CR. We have proposed that CR-induced mitochondrial biogenesis in WAT is mediated by peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), which is transcriptionally regulated by sterol regulatory element-binding protein 1c (SREBP-1c), a master regulator of FA biosynthesis. We have also proposed that the CR-associated upregulation of SREBP-1 and PGC-1α might result from the attenuation of leptin signaling and the upregulation of fibroblast growth factor 21 (FGF21) in WAT. However, the detailed molecular mechanisms remain unclear. Here, we interrogate the regulatory mechanisms involving leptin signaling, SREBP-1c, FGF21, and PGC-1α using
Identifiants
pubmed: 32664386
pii: nu12072054
doi: 10.3390/nu12072054
pmc: PMC7400870
pii:
doi:
Substances chimiques
Fatty Acids
0
Leptin
0
Sterol Regulatory Element Binding Protein 1
0
Transcription Factors
0
fibroblast growth factor 21
0
peroxisome-proliferator-activated receptor-gamma coactivator-1
0
Fibroblast Growth Factors
62031-54-3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : Grants-in-Aid for Scientific Research (B) (No. 17H02179)
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