Evaluation of buccal damage associated with acute inhalation exposure to 2,4-dichlorophenoxyacetic acid (2,4-D) in mice.
Environmental exposure
Inflammation
Leukoplakia
Mast cells
Pesticide exposure
oral
Journal
BMC veterinary research
ISSN: 1746-6148
Titre abrégé: BMC Vet Res
Pays: England
ID NLM: 101249759
Informations de publication
Date de publication:
14 Jul 2020
14 Jul 2020
Historique:
received:
14
02
2020
accepted:
06
07
2020
entrez:
16
7
2020
pubmed:
16
7
2020
medline:
9
3
2021
Statut:
epublish
Résumé
The herbicide dichlorophenoxyacetic acid (2,4-D) is one of the most widely used crop spraying products in the world. Some pesticides induce the degranulation of mast cells and increase allergic responses. This is the first study to evaluate the damage to the oral mucosa after an experimental simulation of environmental inhalation exposure to the 2,4-D herbicide. The aim of this study was evaluate the possible oral damage caused by acute inhalation exposure to the herbicide 2,4-D. There was a difference between the exposure concentrations in relation to tissue congestion intensity (p = 0.002) and mast cell counts (p = 0.002), a difference in the evaluation of the interaction between the exposure concentrations and nebulization time in the dorsum epithelium thickness (p = 0.013), and a significant correlation between the epithelial thickness and the number of nucleoli organizing regions on the dorsum of the tongue (p = 0.048). Even after acute exposure, the herbicide 2,4-D had the potential to damage the oral epithelium, especially at higher doses.
Sections du résumé
BACKGROUND
BACKGROUND
The herbicide dichlorophenoxyacetic acid (2,4-D) is one of the most widely used crop spraying products in the world. Some pesticides induce the degranulation of mast cells and increase allergic responses. This is the first study to evaluate the damage to the oral mucosa after an experimental simulation of environmental inhalation exposure to the 2,4-D herbicide. The aim of this study was evaluate the possible oral damage caused by acute inhalation exposure to the herbicide 2,4-D.
RESULTS
RESULTS
There was a difference between the exposure concentrations in relation to tissue congestion intensity (p = 0.002) and mast cell counts (p = 0.002), a difference in the evaluation of the interaction between the exposure concentrations and nebulization time in the dorsum epithelium thickness (p = 0.013), and a significant correlation between the epithelial thickness and the number of nucleoli organizing regions on the dorsum of the tongue (p = 0.048).
CONCLUSIONS
CONCLUSIONS
Even after acute exposure, the herbicide 2,4-D had the potential to damage the oral epithelium, especially at higher doses.
Identifiants
pubmed: 32664986
doi: 10.1186/s12917-020-02461-w
pii: 10.1186/s12917-020-02461-w
pmc: PMC7362426
doi:
Substances chimiques
Herbicides
0
2,4-Dichlorophenoxyacetic Acid
2577AQ9262
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
244Références
Paediatr Child Health. 2006 Apr;11(4):229-34
pubmed: 19030278
An Bras Dermatol. 2010 Nov-Dec;85(6):811-8
pubmed: 21308304
Toxicol Lett. 2010 Dec 15;199(3):347-56
pubmed: 20920556
Genetika. 1996 Dec;32(12):1700-4
pubmed: 9102364
Zh Mikrobiol Epidemiol Immunobiol. 1999 Nov-Dec;(6):67-70
pubmed: 10876855
Histochem J. 1986 Jan;18(1):5-14
pubmed: 2423479
J Inflamm (Lond). 2004 Sep 27;1(1):1
pubmed: 15813979
Toxicol Sci. 2005 Sep;87(1):123-33
pubmed: 15976183
Pathol Res Pract. 1999;195(6):421-6
pubmed: 10399183
J Integr Plant Biol. 2014 Feb;56(2):106-13
pubmed: 24237670
Stomatologiia (Mosk). 2004;83(1):14-8
pubmed: 15021869
J Toxicol Environ Health A. 2003 Dec 26;66(24):2299-313
pubmed: 14630522
J Immunotoxicol. 2015 Jul-Sep;12(3):283-9
pubmed: 25418051
Toxicology. 2009 Jul 10;261(3):152-61
pubmed: 19467290
J Toxicol Environ Health. 1982 Oct-Nov;10(4-5):729-41
pubmed: 7161824