Retinoic acid synthesis and autoregulation mediate zonal patterning of vestibular organs and inner ear morphogenesis.
ALDH1a3
CYP26b1
Patterning
RDH10
Retinoic acid
Striola
Journal
Development (Cambridge, England)
ISSN: 1477-9129
Titre abrégé: Development
Pays: England
ID NLM: 8701744
Informations de publication
Date de publication:
07 08 2020
07 08 2020
Historique:
received:
27
04
2020
accepted:
01
07
2020
pubmed:
16
7
2020
medline:
24
3
2021
entrez:
16
7
2020
Statut:
epublish
Résumé
Retinoic acid (RA), a vitamin A (retinol) derivative, has pleiotropic functions during embryonic development. The synthesis of RA requires two enzymatic reactions: oxidation of retinol into retinaldehyde by alcohol dehydrogenases (ADHs) or retinol dehydrogenases (RDHs); and oxidation of retinaldehyde into RA by aldehyde dehydrogenases family 1, subfamily A (ALDH1as), such as ALDH1a1, ALDH1a2 and ALDH1a3. Levels of RA in tissues are regulated by spatiotemporal expression patterns of genes encoding RA-synthesizing and -degrading enzymes, such as cytochrome P450 26 (Cyp26 genes). Here, we show that RDH10 is important for both sensory and non-sensory formation of the vestibule of the inner ear. Mice deficient in
Identifiants
pubmed: 32665247
pii: dev.192070
doi: 10.1242/dev.192070
pmc: PMC7420839
pii:
doi:
Substances chimiques
Tretinoin
5688UTC01R
Alcohol Oxidoreductases
EC 1.1.-
trans-retinol dehydrogenase
EC 1.1.1.-
Cyp26b1 protein, mouse
EC 1.14.14.1
Retinoic Acid 4-Hydroxylase
EC 1.14.14.1
Retinal Dehydrogenase
EC 1.2.1.36
retinaldehyde dehydrogenase 3, mouse
EC 1.2.1.36
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE016082
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD077260
Pays : United States
Informations de copyright
© 2020. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.
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