Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice.
COVID-19
GS-441524
RNA-dependent RNA polymerase
RdRp
SARS-CoV-2
antiviral
coronavirus
mouse
remdesivir
therapeutic
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
21 07 2020
21 07 2020
Historique:
received:
21
04
2020
revised:
02
06
2020
accepted:
30
06
2020
pubmed:
16
7
2020
medline:
16
7
2020
entrez:
16
7
2020
Statut:
ppublish
Résumé
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the novel viral disease COVID-19. With no approved therapies, this pandemic illustrates the urgent need for broad-spectrum antiviral countermeasures against SARS-CoV-2 and future emerging CoVs. We report that remdesivir (RDV) potently inhibits SARS-CoV-2 replication in human lung cells and primary human airway epithelial cultures (EC
Identifiants
pubmed: 32668216
pii: S2211-1247(20)30921-9
doi: 10.1016/j.celrep.2020.107940
pmc: PMC7340027
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
107940Subventions
Organisme : NIAID NIH HHS
ID : T32 AI007151
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI108197
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI142759
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI132178
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK065988
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors affiliated with Gilead Sciences, Inc. are employees of the company and may own company stock.
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