Tomas Cihlar

Affiliations

Gilead Sciences, Foster City, CA, USA.

Publications (54)

A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model.

Nature medicine

Avec: Stephen R Yant , Andrew Mulato , Derek Hansen , Winston C Tse , Anita Niedziela-Majka , Jennifer R Zhang , George J Stepan , Debi Jin , Melanie H Wong , Jill M Perreira , Eric Singer , Giuseppe A Papalia , Eric Y Hu , Jim Zheng , Bing Lu , Scott D Schroeder , Kevin Chou , Shekeba Ahmadyar , Albert Liclican , Helen Yu , Nikolai Novikov , Eric Paoli , Daniel Gonik , Renee R Ram , Magdeleine Hung , William M McDougall , Abraham L Brass , Wesley I Sundquist , Tomas Cihlar , John O Link

Identification of NK Cell Subpopulations That Differentiate HIV-Infected Subject Cohorts with Diverse Levels of Virus Control.

Journal of virology

Avec: Christopher W Pohlmeyer , Veronica D Gonzalez , Alivelu Irrinki , Ricardo N Ramirez , Li Li , Andrew Mulato , Jeffrey P Murry , Aaron Arvey , Rebecca Hoh , Steven G Deeks , George Kukolj , Tomas Cihlar , Stefan Pflanz , Garry P Nolan , Gundula Min-Oo

A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19.

bioRxiv : the preprint server for biology

Avec: Xuping Xie , Antonio E Muruato , Xianwen Zhang , Kumari G Lokugamage , Camila R Fontes-Garfias , Jing Zou , Jianying Liu , Ping Ren , Mini Balakrishnan , Tomas Cihlar , Chien-Te K Tseng , Shinji Makino , Vineet D Menachery , John P Bilello , Pei-Yong Shi

Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Emmie de Wit , Friederike Feldmann , Jacqueline Cronin , Robert Jordan , Atsushi Okumura , Tina Thomas , Dana Scott , Tomas Cihlar , Heinz Feldmann

Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus.

Scientific reports

Avec: Travis K Warren , Christopher D Kane , Jay Wells , Kelly S Stuthman , Sean A Van Tongeren , Nicole L Garza , Ginger Donnelly , Jesse Steffens , Laura Gomba , Jessica M Weidner , Sarah Norris , Xiankun Zeng , Roy Bannister , Tomas Cihlar , Sina Bavari , Danielle P Porter , Patrick L Iversen

Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants.

Antimicrobial agents and chemotherapy

Avec: Jared Pitts , Jiani Li , Jason K Perry , Venice Du Pont , Nicholas Riola , Lauren Rodriguez , Xianghan Lu , Chaitanya Kurhade , Xuping Xie , Gregory Camus , Savrina Manhas , Ross Martin , Pei-Yong Shi , Tomas Cihlar , Danielle P Porter , Hongmei Mo , Evguenia Maiorova , John P Bilello

Discovery of GS-7682, a Novel 4'-Cyano-Modified

Journal of medicinal chemistry

Avec: Dustin S Siegel , Hon C Hui , Jared Pitts , Meghan S Vermillion , Kazuya Ishida , Davin Rautiola , Michael Keeney , Hammad Irshad , Lijun Zhang , Kwon Chun , Gregory Chin , Bindu Goyal , Edward Doerffler , Hai Yang , Michael O Clarke , Chris Palmiotti , Arya Vijjapurapu , Nicholas C Riola , Kirsten Stray , Eisuke Murakami , Bin Ma , Ting Wang , Xiaofeng Zhao , Yili Xu , Gary Lee , Bruno Marchand , Minji Seung , Arabinda Nayak , Adrian Tomkinson , Nani Kadrichu , Scott Ellis , Ona Barauskas , Joy Y Feng , Jason K Perry , Michel Perron , John P Bilello , Philip J Kuehl , Raju Subramanian , Tomas Cihlar , Richard L Mackman

Effect of remdesivir post-exposure prophylaxis and treatment on pathogenesis of measles in rhesus macaques.

Scientific reports

Avec: Nadine A Peart Akindele , Laharika Dasharath Katamoni , Jacqueline Brockhurst , Shristi Ghimire , San Suwanmanee , Lisa Pieterse , Kelly A Metcalf Pate , Elaine Bunyan , Roy Bannister , Tomas Cihlar , Danielle P Porter , Diane E Griffin

Characterization of the Cynomolgus Macaque Model of Marburg Virus Disease and Assessment of Timing for Therapeutic Treatment Testing.

Viruses

Avec: Elizabeth E Zumbrun , Carly B Garvey , Jay B Wells , Ginger C Lynn , Sean Van Tongeren , Jesse T Steffens , Kelly S Wetzel , Laura M Gomba , Kristan A O'Brien , Franco D Rossi , Xiankun Zeng , Eric D Lee , Jo Lynne W Raymond , Diana A Hoffman , Alexandra N Jay , Elizabeth S Brown , Paul A Kallgren , Sarah L Norris , Jean Cantey-Kiser , Humza Kudiya , Chris Arthur , Christiana Blair , Darius Babusis , Victor C Chu , Bali Singh , Roy Bannister , Danielle P Porter , Tomas Cihlar , John M Dye

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice.

Cell reports

Avec: Andrea J Pruijssers , Amelia S George , Alexandra Schäfer , Sarah R Leist , Lisa E Gralinksi , Kenneth H Dinnon , Boyd L Yount , Maria L Agostini , Laura J Stevens , James D Chappell , Xiaotao Lu , Tia M Hughes , Kendra Gully , David R Martinez , Ariane J Brown , Rachel L Graham , Jason K Perry , Venice Du Pont , Jared Pitts , Bin Ma , Darius Babusis , Eisuke Murakami , Joy Y Feng , John P Bilello , Danielle P Porter , Tomas Cihlar , Ralph S Baric , Mark R Denison , Timothy P Sheahan

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2.

bioRxiv : the preprint server for biology

Avec: Brandi N Williamson , Friederike Feldmann , Benjamin Schwarz , Kimberly Meade-White , Danielle P Porter , Jonathan Schulz , Neeltje van Doremalen , Ian Leighton , Claude Kwe Yinda , Lizzette Pérez-Pérez , Atsushi Okumura , Jamie Lovaglio , Patrick W Hanley , Greg Saturday , Catharine M Bosio , Sarah Anzick , Kent Barbian , Tomas Cihlar , Craig Martens , Dana P Scott , Vincent J Munster , Emmie de Wit

Drug Resistance Assessment Following Administration of Respiratory Syncytial Virus (RSV) Fusion Inhibitor Presatovir to Participants Experimentally Infected With RSV.

The Journal of infectious diseases

Avec: Kirsten Stray , Michel Perron , Danielle P Porter , Francisco Anderson , Sandra A Lewis , Jason Perry , Michael Miller , Tomas Cihlar , John DeVincenzo , Jason W Chien , Robert Jordan

PREVAIL IV: A Randomized, Double-Blind, 2-Phase, Phase 2 Trial of Remdesivir vs Placebo for Reduction of Ebola Virus RNA in the Semen of Male Survivors.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Avec: Elizabeth S Higgs , Dehkontee Gayedyu-Dennis , William A Fischer Ii , Martha Nason , Cavan Reilly , Abdoul Habib Beavogui , Jamila Aboulhab , Jacqueline Nordwall , Princess Lobbo , Ian Wachekwa , Huyen Cao , Tomas Cihlar , Lisa Hensley , H Clifford Lane

Mining for humoral correlates of HIV control and latent reservoir size.

PLoS pathogens

Avec: Jishnu Das , Anush Devadhasan , Caitlyn Linde , Tom Broge , Jessica Sassic , Max Mangano , Sean O'Keefe , Todd Suscovich , Hendrik Streeck , Alivelu Irrinki , Chris Pohlmeyer , Gundula Min-Oo , Shu Lin , Joshua A Weiner , Thomas Cihlar , Margaret E Ackerman , Boris Julg , Steven Deeks , Douglas A Lauffenburger , Galit Alter

A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19.

Nature communications

Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice.

bioRxiv : the preprint server for biology

Avec: Alexandra Schäfer , David R Martinez , John J Won , Fernando R Moreira , Ariane J Brown , Kendra L Gully , Rao Kalla , Kwon Chun , Venice Du Pont , Darius Babusis , Jennifer Tang , Eisuke Murakami , Raju Subramanian , Kimberly T Barrett , Blake J Bleier , Roy Bannister , Joy Y Feng , John P Bilello , Tomas Cihlar , Richard L Mackman , Stephanie A Montgomery , Ralph S Baric , Timothy P Sheahan

Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets.

Nature communications

Avec: Robert M Cox , Josef D Wolf , Carolin M Lieber , Julien Sourimant , Michelle J Lin , Darius Babusis , Venice DuPont , Julie Chan , Kim T Barrett , Diane Lye , Rao Kalla , Kwon Chun , Richard L Mackman , Chengjin Ye , Tomas Cihlar , Luis Martinez-Sobrido , Alexander L Greninger , John P Bilello , Richard K Plemper

Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection.

Science translational medicine

Avec: Meghan S Vermillion , Eisuke Murakami , Bin Ma , Jared Pitts , Adrian Tomkinson , Davin Rautiola , Darius Babusis , Hammad Irshad , Dustin Seigel , Cynthia Kim , Xiaofeng Zhao , Congrong Niu , Jesse Yang , Andrew Gigliotti , Nani Kadrichu , John P Bilello , Scott Ellis , Roy Bannister , Raju Subramanian , Bill Smith , Richard L Mackman , William A Lee , Philip J Kuehl , Jim Hartke , Tomas Cihlar , Danielle P Porter

Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys.

Journal of medicinal chemistry

Avec: Richard L Mackman , Rao V Kalla , Darius Babusis , Jared Pitts , Kimberly T Barrett , Kwon Chun , Venice Du Pont , Lauren Rodriguez , Jasmine Moshiri , Yili Xu , Michael Lee , Gary Lee , Blake Bleier , Anh-Quan Nguyen , B Michael O'Keefe , Andrea Ambrosi , Meredith Cook , Joy Yu , Kassibla Elodie Dempah , Elaine Bunyan , Nicholas C Riola , Xianghan Lu , Renmeng Liu , Ashley Davie , Tien-Ying Hsiang , Justin Dearing , Meghan Vermillion , Michael Gale , Anita Niedziela-Majka , Joy Y Feng , Charlotte Hedskog , John P Bilello , Raju Subramanian , Tomas Cihlar

Late remdesivir treatment initiation partially protects African green monkeys from lethal Nipah virus infection.

Antiviral research

Avec: Emmie de Wit , Brandi N Williamson , Friederike Feldmann , Kerry Goldin , Michael K Lo , Atsushi Okumura , Jamie Lovaglio , Elaine Bunyan , Danielle P Porter , Tomas Cihlar , Greg Saturday , Christina F Spiropoulou , Heinz Feldmann

The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses.

Science translational medicine

Avec: David R Martinez , Fernando R Moreira , Nicholas J Catanzaro , Meghan V Diefenbacher , Mark R Zweigart , Kendra L Gully , Gabriela De la Cruz , Ariane J Brown , Lily E Adams , Boyd Yount , Thomas J Baric , Michael L Mallory , Helen Conrad , Samantha R May , Stephanie Dong , D Trevor Scobey , Cameron Nguyen , Stephanie A Montgomery , Jason K Perry , Darius Babusis , Kimberly T Barrett , Anh-Hoa Nguyen , Anh-Quan Nguyen , Rao Kalla , Roy Bannister , Joy Y Feng , Tomas Cihlar , Ralph S Baric , Richard L Mackman , John P Bilello , Alexandra Schäfer , Timothy P Sheahan

Characterization of Ebola Virus Disease (EVD) in Rhesus Monkeys for Development of EVD Therapeutics.

Viruses

Avec: Travis Warren , Elizabeth Zumbrun , Jessica M Weidner , Laura Gomba , Franco Rossi , Roy Bannister , Jacqueline Tarrant , Matthew Reed , Eric Lee , Jo Lynne Raymond , Jay Wells , Joshua Shamblin , Kelly Wetzel , Ginger Donnelly , Sean Van Tongeren , Nicole Lackemeyer , Jesse Steffens , Adrienne Kimmel , Carly Garvey , Holly Bloomfield , Christiana Blair , Bali Singh , Sina Bavari , Tomas Cihlar , Danielle Porter

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase.

Antiviral research

Avec: Ariane J Brown , John J Won , Rachel L Graham , Kenneth H Dinnon , Amy C Sims , Joy Y Feng , Tomas Cihlar , Mark R Denison , Ralph S Baric , Timothy P Sheahan

Subcutaneous remdesivir administration prevents interstitial pneumonia in rhesus macaques inoculated with SARS-CoV-2.

Antiviral research

Avec: Brandi N Williamson , Lizzette Pérez-Pérez , Benjamin Schwarz , Friederike Feldmann , Myndi G Holbrook , Manmeet Singh , Diane S Lye , Darius Babusis , Raju Subramanian , Elaine Haddock , Atsushi Okumura , Patrick W Hanley , Jamie Lovaglio , Catharine M Bosio , Danielle P Porter , Tomas Cihlar , Richard L Mackman , Greg Saturday , Emmie de Wit

Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit.

The Journal of infectious diseases

Avec: Matthew D Hall , James M Anderson , Annaliesa Anderson , David Baker , Jay Bradner , Kyle R Brimacombe , Elizabeth A Campbell , Kizzmekia S Corbett , Kara Carter , Sara Cherry , Lillian Chiang , Tomas Cihlar , Emmie de Wit , Mark Denison , Matthew Disney , Courtney V Fletcher , Stephanie L Ford-Scheimer , Matthias Götte , Abigail C Grossman , Frederick G Hayden , Daria J Hazuda , Charlotte A Lanteri , Hilary Marston , Andrew D Mesecar , Stephanie Moore , Jennifer O Nwankwo , Jules O'Rear , George Painter , Kumar Singh Saikatendu , Celia A Schiffer , Timothy P Sheahan , Pei-Yong Shi , Hugh D Smyth , Michael J Sofia , Marla Weetall , Sandra K Weller , Richard Whitley , Anthony S Fauci , Christopher P Austin , Francis S Collins , Anthony J Conley , Mindy I Davis

Forgiveness of INSTI-Containing Regimens at Drug Concentrations Simulating Variable Adherence

Antimicrobial agents and chemotherapy

Avec: Rima K Acosta , Michelle L D'Antoni , Andrew Mulato , Stephen R Yant , Tomas Cihlar , Kirsten L White

Ongoing viral replication and production of infectious virus in patients with chronic hepatitis B virus suppressed below the limit of quantitation on long-term nucleos(t)ide therapy.

PloS one

Avec: Dara L Burdette , Scott Lazerwith , Jenny Yang , Henry L Y Chan , William E Delaney Iv , Simon P Fletcher , Tomas Cihlar , Becket Feierbach

Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro.

Scientific reports

Avec: Sheli R Radoshitzky , Patrick Iversen , Xianghan Lu , Jing Zou , Suzanne J F Kaptein , Kelly S Stuthman , Sean A Van Tongeren , Jesse Steffens , Ruoyu Gong , Hoa Truong , Annapurna A Sapre , Huiling Yang , Xiaodong Xie , Jia Jun Chia , Zhijuan J Song , Stacey M Leventhal , Josolyn Chan , Alex Shornikov , Xin Zhang , David Cowfer , Helen Yu , Travis Warren , Tomas Cihlar , Danielle P Porter , Johan Neyts , Pei-Yong Shi , Jay Wells , John P Bilello , Joy Y Feng

Efficacy of the oral nucleoside prodrug GS-5245 (Obeldesivir) against SARS-CoV-2 and coronaviruses with pandemic potential.

bioRxiv : the preprint server for biology

Avec: David R Martinez , Fernando R Moreira , Mark R Zweigart , Kendra L Gully , Gabriela De la Cruz , Ariane J Brown , Lily E Adams , Nicholas Catanzaro , Boyd Yount , Thomas J Baric , Michael L Mallory , Helen Conrad , Samantha R May , Stephanie Dong , D Trevor Scobey , Stephanie A Montgomery , Jason Perry , Darius Babusis , Kimberly T Barrett , Anh-Hoa Nguyen , Anh-Quan Nguyen , Rao Kalla , Roy Bannister , John P Bilello , Joy Y Feng , Tomas Cihlar , Ralph S Baric , Richard L Mackman , Alexandra Schäfer , Timothy P Sheahan

No virologic resistance to bulevirtide monotherapy detected in patients through 24 weeks treatment in phase II and III clinical trials for chronic hepatitis delta.

Journal of hepatology

Avec: Julius Hollnberger , Yang Liu , Simin Xu , Silvia Chang , Ross Martin , Savrina Manhas , Thomas Aeschbacher , Bin Han , Tahmineh Yazdi , Lindsey May , Dong Han , Alex Shornikov , John Flaherty , Dmitry Manuilov , Vithika Suri , Tarik Asselah , Pietro Lampertico , Heiner Wedemeyer , Soo Aleman , Christopher Richards , Roberto Mateo , Evguenia Maiorova , Tomas Cihlar , Hongmei Mo , Stephan Urban

Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice.

bioRxiv : the preprint server for biology

Remdesivir (GS-5734) Is Efficacious in Cynomolgus Macaques Infected With Marburg Virus.

The Journal of infectious diseases

Avec: Danielle P Porter , Jessica M Weidner , Laura Gomba , Roy Bannister , Christiana Blair , Robert Jordan , Jay Wells , Kelly Wetzel , Nicole Garza , Sean Van Tongeren , Ginger Donnelly , Jesse Steffens , Alicia Moreau , Jeremy Bearss , Eric Lee , Sina Bavari , Tomas Cihlar , Travis K Warren

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.

Nature communications

Avec: Timothy P Sheahan , Amy C Sims , Sarah R Leist , Alexandra Schäfer , John Won , Ariane J Brown , Stephanie A Montgomery , Alison Hogg , Darius Babusis , Michael O Clarke , Jamie E Spahn , Laura Bauer , Scott Sellers , Danielle Porter , Joy Y Feng , Tomas Cihlar , Robert Jordan , Mark R Denison , Ralph S Baric

Remdesivir (GS-5734) protects African green monkeys from Nipah virus challenge.

Science translational medicine

Avec: Michael K Lo , Friederike Feldmann , Joy M Gary , Robert Jordan , Roy Bannister , Jacqueline Cronin , Nishi R Patel , John D Klena , Stuart T Nichol , Tomas Cihlar , Sherif R Zaki , Heinz Feldmann , Christina F Spiropoulou , Emmie de Wit

Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine

Journal of medicinal chemistry

Avec: Richard L Mackman , Hon C Hui , Michel Perron , Eisuke Murakami , Christopher Palmiotti , Gary Lee , Kirsten Stray , Lijun Zhang , Bindu Goyal , Kwon Chun , Daniel Byun , Dustin Siegel , Scott Simonovich , Venice Du Pont , Jared Pitts , Darius Babusis , Arya Vijjapurapu , Xianghan Lu , Cynthia Kim , Xiaofeng Zhao , Julie Chan , Bin Ma , Diane Lye , Adelle Vandersteen , Sarah Wortman , Kimberly T Barrett , Maria Toteva , Robert Jordan , Raju Subramanian , John P Bilello , Tomas Cihlar

Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice.

bioRxiv : the preprint server for biology

Avec: David R Martinez , Alexandra Schaefer , Sarah R Leist , Dapeng Li , Kendra Gully , Boyd Yount , Joy Y Feng , Elaine Bunyan , Danielle P Porter , Tomas Cihlar , Stephanie A Montgomery , Barton F Haynes , Ralph S Baric , Michel C Nussenzweig , Timothy P Sheahan

Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms.

Science translational medicine

Avec: Laura J Stevens , Andrea J Pruijssers , Hery W Lee , Calvin J Gordon , Egor P Tchesnokov , Jennifer Gribble , Amelia S George , Tia M Hughes , Xiaotao Lu , Jiani Li , Jason K Perry , Danielle P Porter , Tomas Cihlar , Timothy P Sheahan , Ralph S Baric , Matthias Götte , Mark R Denison

Intravenous delivery of GS-441524 is efficacious in the African green monkey model of SARS-CoV-2 infection.

Antiviral research

Avec: Jared Pitts , Darius Babusis , Meghan S Vermillion , Raju Subramanian , Kim Barrett , Diane Lye , Bin Ma , Xiaofeng Zhao , Nicholas Riola , Xuping Xie , Adriana Kajon , Xianghan Lu , Roy Bannister , Pei-Yong Shi , Maria Toteva , Danielle P Porter , Bill J Smith , Tomas Cihlar , Richard Mackman , John P Bilello

Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice.

Science translational medicine

Avec: Alexandra Schäfer , David R Martinez , John J Won , Rita M Meganck , Fernando R Moreira , Ariane J Brown , Kendra L Gully , Mark R Zweigart , William S Conrad , Samantha R May , Stephanie Dong , Rao Kalla , Kwon Chun , Venice Du Pont , Darius Babusis , Jennifer Tang , Eisuke Murakami , Raju Subramanian , Kimberly T Barrett , Blake J Bleier , Roy Bannister , Joy Y Feng , John P Bilello , Tomas Cihlar , Richard L Mackman , Stephanie A Montgomery , Ralph S Baric , Timothy P Sheahan

The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2.

Molecules (Basel, Switzerland)

Avec: Joy Y Feng , Venice Du Pont , Darius Babusis , Calvin J Gordon , Egor P Tchesnokov , Jason K Perry , Vincent Duong , Arya Vijjapurapu , Xiaofeng Zhao , Julie Chan , Cal Cohen , Kavita Juneja , Tomas Cihlar , Matthias Götte , John P Bilello

Perspectives on Advancing Countermeasures for Filovirus Disease: Report From a Multisector Meeting.

The Journal of infectious diseases

Avec: Armand Sprecher , Robert Cross , Andrea Marzi , Karen A Martins , Daniel Wolfe , Joel M Montgomery , Christina F Spiropoulou , Tomas Cihlar , Steve Ahuka-Mundeke , Tara Nyhuis , Carrie Teicher , Ian Crozier , Jim Strong , Gary Kobinger , Courtney Woolsey , Thomas W Geisbert , Heinz Feldmann , Jean-Jacques Muyembe

Lenacapavir: A Novel, Potent, and Selective First-in-Class Inhibitor of HIV-1 Capsid Function Exhibits Optimal Pharmacokinetic Properties for a Long-Acting Injectable Antiretroviral Agent.

Molecular pharmaceutics

Avec: Raju Subramanian , Jennifer Tang , Jim Zheng , Bing Lu , Kelly Wang , Stephen R Yant , George J Stepan , Andrew Mulato , Helen Yu , Scott Schroeder , Naveed Shaik , Renu Singh , Scott Wolckenhauer , Anne Chester , Winston C Tse , Anna Chiu , Martin Rhee , Tomas Cihlar , William Rowe , Bill J Smith

Oral administration of obeldesivir protects nonhuman primates against

Science (New York, N.Y.)

Avec: Robert W Cross , Courtney Woolsey , Victor C Chu , Darius Babusis , Roy Bannister , Meghan S Vermillion , Romas Geleziunas , Kimberly T Barrett , Elaine Bunyan , Anh-Quan Nguyen , Tomas Cihlar , Danielle P Porter , Abhishek N Prasad , Daniel J Deer , Viktoriya Borisevich , Krystle N Agans , Jasmine Martinez , Mack B Harrison , Natalie S Dobias , Karla A Fenton , John P Bilello , Thomas W Geisbert

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2.

Nature

Clinical targeting of HIV capsid protein with a long-acting small molecule.

Nature

Avec: John O Link , Martin S Rhee , Winston C Tse , Jim Zheng , John R Somoza , William Rowe , Rebecca Begley , Anna Chiu , Andrew Mulato , Derek Hansen , Eric Singer , Luong K Tsai , Rujuta A Bam , Chien-Hung Chou , Eda Canales , Gediminas Brizgys , Jennifer R Zhang , Jiayao Li , Michael Graupe , Philip Morganelli , Qi Liu , Qiaoyin Wu , Randall L Halcomb , Roland D Saito , Scott D Schroeder , Scott E Lazerwith , Steven Bondy , Debi Jin , Magdeleine Hung , Nikolai Novikov , Xiaohong Liu , Armando G Villaseñor , Carina E Cannizzaro , Eric Y Hu , Robert L Anderson , Todd C Appleby , Bing Lu , Judy Mwangi , Albert Liclican , Anita Niedziela-Majka , Giuseppe A Papalia , Melanie H Wong , Stephanie A Leavitt , Yili Xu , David Koditek , George J Stepan , Helen Yu , Nikos Pagratis , Sheila Clancy , Shekeba Ahmadyar , Terrence Z Cai , Scott Sellers , Scott A Wolckenhauer , John Ling , Christian Callebaut , Nicolas Margot , Renee R Ram , Ya-Pei Liu , Rob Hyland , Gary I Sinclair , Peter J Ruane , Gordon E Crofoot , Cheryl K McDonald , Diana M Brainard , Latesh Lad , Swami Swaminathan , Wesley I Sundquist , Roman Sakowicz , Anne E Chester , William E Lee , Eric S Daar , Stephen R Yant , Tomas Cihlar

Long-acting capsid inhibitor protects macaques from repeat SHIV challenges.

Nature

Avec: Samuel J Vidal , Elena Bekerman , Derek Hansen , Bing Lu , Kelly Wang , Judy Mwangi , William Rowe , Federico Campigotto , Jim Zheng , Darryl Kato , Abishek Chandrashekar , Julia Barrett , Shivani Patel , Huahua Wan , Tochi Anioke , Noe B Mercado , Joseph P Nkolola , Melissa J Ferguson , William J Rinaldi , Christian Callebaut , Wade Blair , Tomas Cihlar , Romas Geleziunas , Stephen R Yant , Dan H Barouch

Off-Target

Antimicrobial agents and chemotherapy

Avec: Yili Xu , Ona Barauskas , Cynthia Kim , Darius Babusis , Eisuke Murakami , Dmytro Kornyeyev , Gary Lee , George Stepan , Michel Perron , Roy Bannister , Brian E Schultz , Roman Sakowicz , Danielle Porter , Tomas Cihlar , Joy Y Feng

Simulating HIV Breakthrough and Resistance Development During Variable Adherence to Antiretroviral Treatment.

Journal of acquired immune deficiency syndromes (1999)

Avec: Andrew Mulato , Rima Acosta , Silvia Chang , Ross Martin , Stephen R Yant , Tomas Cihlar , Kirsten White

Two-dose emtricitabine/tenofovir alafenamide plus bictegravir prophylaxis protects macaques against SHIV infection.

The Journal of antimicrobial chemotherapy

Avec: Elena Bekerman , Stephanie Cox , Darius Babusis , Federico Campigotto , Moupali Das , Dan H Barouch , Tomas Cihlar , Christian Callebaut

Genetic conservation of SARS-CoV-2 RNA replication complex in globally circulating isolates and recently emerged variants from humans and minks suggests minimal pre-existing resistance to remdesivir.

Antiviral research

Avec: Ross Martin , Jiani Li , Aiyappa Parvangada , Jason Perry , Tomas Cihlar , Hongmei Mo , Danielle Porter , Evguenia Svarovskaia

A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agents.

Antiviral research

Avec: Thuc Nguyen Dan Do , Kim Donckers , Laura Vangeel , Arnab K Chatterjee , Philippe A Gallay , Michael D Bobardt , John P Bilello , Tomas Cihlar , Steven De Jonghe , Johan Neyts , Dirk Jochmans

Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice.

Cell reports

Avec: David R Martinez , Alexandra Schäfer , Sarah R Leist , Dapeng Li , Kendra Gully , Boyd Yount , Joy Y Feng , Elaine Bunyan , Danielle P Porter , Tomas Cihlar , Stephanie A Montgomery , Barton F Haynes , Ralph S Baric , Michel C Nussenzweig , Timothy P Sheahan

Journey of remdesivir from the inhibition of hepatitis C virus to the treatment of COVID-19.

Antiviral therapy

Avec: Tomas Cihlar , Richard L Mackman

Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability.

Antimicrobial agents and chemotherapy

Avec: Andrew Mulato , Eric Lansdon , Ron Aoyama , Johannes Voigt , Michael Lee , Albert Liclican , Gary Lee , Eric Singer , Brian Stafford , Ruoyu Gong , Bernard Murray , Julie Chan , Johnny Lee , Yili Xu , Shekeba Ahmadyar , Ana Gonzalez , Aesop Cho , George J Stepan , Uli Schmitz , Brian Schultz , Bruno Marchand , Boris Brumshtein , Ruth Wang , Helen Yu , Tomas Cihlar , Lianhong Xu , Stephen R Yant

Réseau de co-auteurs

John P Bilello 19 collaborations

Danielle P Porter 19 collaborations

Darius Babusis 18 collaborations

Joy Y Feng 15 collaborations

Roy Bannister 14 collaborations

Timothy P Sheahan 12 collaborations

Richard L Mackman 11 collaborations

Ralph S Baric 11 collaborations

Raju Subramanian 9 collaborations

Jared Pitts 8 collaborations

Venice Du Pont 8 collaborations

Eisuke Murakami 8 collaborations

Alexandra Schäfer 8 collaborations

David R Martinez 8 collaborations

Ariane J Brown 8 collaborations

Stephen R Yant 7 collaborations

Andrew Mulato 7 collaborations

Emmie de Wit 7 collaborations

Jason K Perry 7 collaborations

Kimberly T Barrett 7 collaborations

Stephanie A Montgomery 7 collaborations

Pei-Yong Shi 6 collaborations

Friederike Feldmann 6 collaborations

Robert Jordan 6 collaborations

Kwon Chun 6 collaborations

Bin Ma 6 collaborations

Elaine Bunyan 6 collaborations

Helen Yu 5 collaborations

Atsushi Okumura 5 collaborations

Xianghan Lu 5 collaborations

Xiaofeng Zhao 5 collaborations

Yili Xu 5 collaborations

Gary Lee 5 collaborations

Sarah R Leist 5 collaborations

Mark R Denison 5 collaborations

Rao Kalla 5 collaborations

George J Stepan 4 collaborations

Jim Zheng 4 collaborations

Bing Lu 4 collaborations

Xuping Xie 4 collaborations

Heinz Feldmann 4 collaborations

Jay Wells 4 collaborations

Jesse Steffens 4 collaborations

Ross Martin 4 collaborations

Meghan S Vermillion 4 collaborations

Michel Perron 4 collaborations

Kendra Gully 4 collaborations

Brandi N Williamson 4 collaborations

Jamie Lovaglio 4 collaborations

Greg Saturday 4 collaborations

Fernando R Moreira 4 collaborations

Kendra L Gully 4 collaborations

Julie Chan 4 collaborations

Anh-Quan Nguyen 4 collaborations

Boyd Yount 4 collaborations

Danielle Porter 4 collaborations

Derek Hansen 3 collaborations

Winston C Tse 3 collaborations

Anita Niedziela-Majka 3 collaborations

Eric Singer 3 collaborations

Shekeba Ahmadyar 3 collaborations

Albert Liclican 3 collaborations

Jing Zou 3 collaborations

Ginger Donnelly 3 collaborations

Laura Gomba 3 collaborations

Jessica M Weidner 3 collaborations

Sina Bavari 3 collaborations

Jiani Li 3 collaborations

Hongmei Mo 3 collaborations

Arya Vijjapurapu 3 collaborations

Kirsten Stray 3 collaborations

Sean Van Tongeren 3 collaborations

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