Discovery of GS-7682, a Novel 4'-Cyano-Modified

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
17 Jul 2024
Historique:
medline: 17 7 2024
pubmed: 17 7 2024
entrez: 17 7 2024
Statut: aheadofprint

Résumé

Acute respiratory viral infections, such as pneumovirus and respiratory picornavirus infections, exacerbate disease in COPD and asthma patients. A research program targeting respiratory syncytial virus (RSV) led to the discovery of GS-7682 (

Identifiants

DOI: 10.1021/acs.jmedchem.4c00899 PMID: 39018526
pubmed: 39018526
doi: 10.1021/acs.jmedchem.4c00899
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Dustin S Siegel (DS)

Gilead Sciences, Inc., Foster City, California 94404, United States.
ORCID: 0009-0008-1365-0287

Hon C Hui (HC)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Jared Pitts (J)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Meghan S Vermillion (MS)

Gilead Sciences, Inc., Foster City, California 94404, United States.
Lovelace Biomedical, Albuquerque, New Mexico 87108, United States.

Kazuya Ishida (K)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Davin Rautiola (D)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Michael Keeney (M)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Hammad Irshad (H)

Lovelace Biomedical, Albuquerque, New Mexico 87108, United States.

Lijun Zhang (L)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Kwon Chun (K)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Gregory Chin (G)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Bindu Goyal (B)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Edward Doerffler (E)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Hai Yang (H)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Michael O Clarke (MO)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Chris Palmiotti (C)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Arya Vijjapurapu (A)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Nicholas C Riola (NC)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Kirsten Stray (K)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Eisuke Murakami (E)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Bin Ma (B)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Ting Wang (T)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Xiaofeng Zhao (X)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Yili Xu (Y)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Gary Lee (G)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Bruno Marchand (B)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Minji Seung (M)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Arabinda Nayak (A)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Adrian Tomkinson (A)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Nani Kadrichu (N)

Inspired - Pulmonary Solutions, San Carlos, California 94070, United States.

Scott Ellis (S)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Ona Barauskas (O)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Joy Y Feng (JY)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Jason K Perry (JK)

Gilead Sciences, Inc., Foster City, California 94404, United States.
ORCID: 0000-0001-5492-0652

Michel Perron (M)

Gilead Sciences, Inc., Foster City, California 94404, United States.

John P Bilello (JP)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Philip J Kuehl (PJ)

Lovelace Biomedical, Albuquerque, New Mexico 87108, United States.
ORCID: 0000-0002-7567-3002

Raju Subramanian (R)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Tomas Cihlar (T)

Gilead Sciences, Inc., Foster City, California 94404, United States.

Richard L Mackman (RL)

Gilead Sciences, Inc., Foster City, California 94404, United States.
ORCID: 0000-0001-8861-7205

Classifications MeSH