Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine

Adenosine Monophosphate / analogs & derivatives Alanine / analogs & derivatives Animals Antiviral Agents / chemistry Caco-2 Cells Cells, Cultured Chlorocebus aethiops Disease Models, Animal Dogs Drug Evaluation, Preclinical / methods Epithelial Cells / virology Humans Macaca fascicularis Male Prodrugs / chemistry Rats, Sprague-Dawley Respiratory Syncytial Virus Infections / drug therapy Respiratory Syncytial Virus, Human / drug effects Structure-Activity Relationship Tissue Distribution Tubercidin / analogs & derivatives Viral Load

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
22 04 2021
Historique:
pubmed: 10 4 2021
medline: 29 4 2021
entrez: 9 4 2021
Statut: ppublish

Résumé

A discovery program targeting respiratory syncytial virus (RSV) identified

Identifiants

DOI: 10.1021/acs.jmedchem.1c00071 PMID: 33835812
pubmed: 33835812
doi: 10.1021/acs.jmedchem.1c00071
doi:

Substances chimiques

Antiviral Agents 0
Prodrugs 0
1,3-dideazaadenosine 20649-47-2
remdesivir 3QKI37EEHE
Adenosine Monophosphate 415SHH325A
Tubercidin M351LCX45Y
Alanine OF5P57N2ZX

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

5001-5017

Auteurs

Richard L Mackman (RL)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
ORCID: 0000-0001-8861-7205

Hon C Hui (HC)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Michel Perron (M)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Eisuke Murakami (E)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Christopher Palmiotti (C)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Gary Lee (G)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Kirsten Stray (K)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Lijun Zhang (L)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Bindu Goyal (B)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Kwon Chun (K)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Daniel Byun (D)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Dustin Siegel (D)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Scott Simonovich (S)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Venice Du Pont (V)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Jared Pitts (J)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Darius Babusis (D)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Arya Vijjapurapu (A)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Xianghan Lu (X)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Cynthia Kim (C)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Xiaofeng Zhao (X)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Julie Chan (J)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Bin Ma (B)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
ORCID: 0000-0002-7549-2658

Diane Lye (D)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Adelle Vandersteen (A)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Sarah Wortman (S)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Kimberly T Barrett (KT)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Maria Toteva (M)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Robert Jordan (R)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Raju Subramanian (R)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

John P Bilello (JP)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

Tomas Cihlar (T)

Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › AMP › Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Alanine › Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine
questionsmedicales.fr › Eucaryotes › Animaux › Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Caco-2 › Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine
questionsmedicales.fr › Cellules › Cellules cultivées › Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Cercopithecus › Cercopithecus aethiops › Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine
questionsmedicales.fr › Cellules › Cellules épithéliales › Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca fascicularis › Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine
questionsmedicales.fr › Préparations pharmaceutiques › Promédicaments › Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Mononegavirales › Infections à Paramyxoviridae › Infections à pneumovirus › Infections à virus respiratoire syncytial › Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Mononegavirales › Paramyxoviridae › Pneumovirinae › Pneumovirus › Virus respiratoires syncytiaux › Virus respiratoire syncytial humain › Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Tubercidine › Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Charge virale › Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine