Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase.
Adenosine Monophosphate
/ analogs & derivatives
Alanine
/ analogs & derivatives
Animals
Antiviral Agents
/ pharmacology
Betacoronavirus
/ drug effects
Cell Line
Coronavirus
/ classification
Coronavirus Infections
/ drug therapy
Humans
Middle East Respiratory Syndrome Coronavirus
/ drug effects
Phylogeny
RNA-Dependent RNA Polymerase
/ antagonists & inhibitors
Severe acute respiratory syndrome-related coronavirus
/ drug effects
Swine
Virus Replication
/ drug effects
Broad-spectrum antivirals
Coronavirus
Emerging viruses
GS-5743
Remdesivir
Journal
Antiviral research
ISSN: 1872-9096
Titre abrégé: Antiviral Res
Pays: Netherlands
ID NLM: 8109699
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
20
02
2019
revised:
18
06
2019
accepted:
19
06
2019
pubmed:
25
6
2019
medline:
8
7
2020
entrez:
25
6
2019
Statut:
ppublish
Résumé
The genetically diverse Orthocoronavirinae (CoV) family is prone to cross species transmission and disease emergence in both humans and livestock. Viruses similar to known epidemic strains circulating in wild and domestic animals further increase the probability of emergence in the future. Currently, there are no approved therapeutics for any human CoV presenting a clear unmet medical need. Remdesivir (RDV, GS-5734) is a monophosphoramidate prodrug of an adenosine analog with potent activity against an array of RNA virus families including Filoviridae, Paramyxoviridae, Pneumoviridae, and Orthocoronavirinae, through the targeting of the viral RNA dependent RNA polymerase (RdRp). We developed multiple assays to further define the breadth of RDV antiviral activity against the CoV family. Here, we show potent antiviral activity of RDV against endemic human CoVs OC43 (HCoV-OC43) and 229E (HCoV-229E) with submicromolar EC
Identifiants
pubmed: 31233808
pii: S0166-3542(19)30099-3
doi: 10.1016/j.antiviral.2019.104541
pmc: PMC6699884
mid: NIHMS1532872
pii:
doi:
Substances chimiques
Antiviral Agents
0
remdesivir
3QKI37EEHE
Adenosine Monophosphate
415SHH325A
RNA-Dependent RNA Polymerase
EC 2.7.7.48
Alanine
OF5P57N2ZX
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
104541Subventions
Organisme : NIAID NIH HHS
ID : R01 AI132178
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007419
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI109680
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI142759
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
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