CD4
Adult
Amino Acid Motifs
Amino Acid Sequence
Animals
Birds
/ virology
CD4-Positive T-Lymphocytes
/ immunology
Complementarity Determining Regions
/ chemistry
Conserved Sequence
Epitopes
/ chemistry
Female
Germ Cells
/ metabolism
HLA-DR1 Antigen
/ immunology
Humans
Immunodominant Epitopes
/ chemistry
Immunoglobulin Variable Region
/ genetics
Influenza A virus
/ immunology
Male
Middle Aged
Peptides
/ chemistry
Receptors, Antigen, T-Cell
/ metabolism
Swine
/ virology
Tissue Donors
Viral Proteins
/ immunology
Young Adult
Zoonoses
/ immunology
CD4 T cells
HLA class II
T cell receptor
X-ray crystallography
biochemistry
clonotyping
immunology
influenza
pHLA mutlimer
peptide epitopes
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
14 07 2020
14 07 2020
Historique:
received:
17
03
2019
revised:
20
01
2020
accepted:
17
06
2020
entrez:
16
7
2020
pubmed:
16
7
2020
medline:
30
4
2021
Statut:
ppublish
Résumé
T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by using identical or highly related TCRs expressed on CD8
Identifiants
pubmed: 32668259
pii: S2211-1247(20)30866-4
doi: 10.1016/j.celrep.2020.107885
pmc: PMC7370177
pii:
doi:
Substances chimiques
Complementarity Determining Regions
0
Epitopes
0
HLA-DR1 Antigen
0
Immunodominant Epitopes
0
Immunoglobulin Variable Region
0
Peptides
0
Receptors, Antigen, T-Cell
0
Viral Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
107885Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/H001085/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : HHSN272201400006C
Pays : United States
Organisme : Wellcome Trust
ID : WT100327MA
Pays : United Kingdom
Organisme : Cancer Research UK
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT095767
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
Références
J Immunol. 2002 Apr 15;168(8):3894-901
pubmed: 11937544
J Immunol. 2015 Jan 1;194(1):463-74
pubmed: 25452566
Nucleic Acids Res. 2020 Jan 8;48(D1):D1057-D1062
pubmed: 31588507
J Exp Med. 2002 Mar 4;195(5):571-81
pubmed: 11877480
EMBO J. 2000 Nov 1;19(21):5611-24
pubmed: 11060013
J Immunol. 2018 Apr 1;200(7):2263-2279
pubmed: 29483360
Immunogenetics. 2015 Nov;67(11-12):641-50
pubmed: 26416257
Nat Commun. 2012 Feb 07;3:665
pubmed: 22314361
Science. 1999 Oct 29;286(5441):958-61
pubmed: 10542151
Structure. 2016 Oct 4;24(10):1643-1657
pubmed: 27568928
J Exp Med. 2005 Nov 21;202(10):1349-61
pubmed: 16287711
Cell Rep. 2017 Apr 18;19(3):569-583
pubmed: 28423320
J Immunol Methods. 2016 Mar;430:43-50
pubmed: 26826277
Acta Crystallogr D Biol Crystallogr. 1994 Sep 1;50(Pt 5):760-3
pubmed: 15299374
Bioinformatics. 2019 Sep 1;35(17):2974-2981
pubmed: 30657870
Front Immunol. 2018 Apr 11;9:674
pubmed: 29696015
Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):235-42
pubmed: 21460441
BMC Bioinformatics. 2015 May 28;16:175
pubmed: 26017500
Semin Pediatr Infect Dis. 2002 Apr;13(2):72-8
pubmed: 12122955
J Immunol. 2016 Jun 15;196(12):5005-13
pubmed: 27183615
Am J Respir Crit Care Med. 2015 Jun 15;191(12):1422-31
pubmed: 25844934
Sci Immunol. 2018 Jun 8;3(24):
pubmed: 29884618
Nucleic Acids Res. 2015 Jan;43(Database issue):D413-22
pubmed: 25378316
Nat Immunol. 2007 Sep;8(9):975-83
pubmed: 17694060
PLoS One. 2007 Nov 21;2(11):e1190
pubmed: 18030326
Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):355-67
pubmed: 21460454
J Immunol. 2000 Aug 15;165(4):2001-11
pubmed: 10925283
Nat Med. 2012 Jan 29;18(2):274-80
pubmed: 22286307
Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14960-5
pubmed: 22930819
Cell. 1988 Feb 26;52(4):515-23
pubmed: 2963699
Nat Immunol. 2016 Jan;17(1):87-94
pubmed: 26523866
Bioinformatics. 2017 Nov 15;33(22):3645-3647
pubmed: 29036507
Bioinformatics. 2014 May 1;30(9):1312-3
pubmed: 24451623
J Immunol. 2000 Nov 1;165(9):4831-41
pubmed: 11046006
Cold Spring Harb Protoc. 2011 Jun 01;2011(6):716-25
pubmed: 21632777
Nat Struct Mol Biol. 2017 Apr;24(4):395-406
pubmed: 28250417
Nature. 2017 Jul 6;547(7661):94-98
pubmed: 28636589
Bioinformatics. 2019 Feb 1;35(3):526-528
pubmed: 30016406
J Immunol. 2008 Feb 1;180(3):1758-68
pubmed: 18209073
Nat Methods. 2015 May;12(5):380-1
pubmed: 25924071
Immunogenetics. 2002 Dec;54(9):611-20
pubmed: 12466894
Front Immunol. 2016 Jan 25;7:10
pubmed: 26834750
Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4440-5
pubmed: 27036003
PLoS Comput Biol. 2015 Nov 25;11(11):e1004503
pubmed: 26606115
Bioinformatics. 2014 Oct;30(19):2811-2
pubmed: 24930139
J Virol. 2014 Oct;88(20):11760-73
pubmed: 25078703
Nat Immunol. 2005 Feb;6(2):171-80
pubmed: 15640805
Nat Med. 2013 Oct;19(10):1305-12
pubmed: 24056771
Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10037-41
pubmed: 11517324
Nat Immunol. 2003 Jul;4(7):657-63
pubmed: 12796775
Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32
pubmed: 15572765
Immunology. 2015 Sep;146(1):11-22
pubmed: 26076649
Bioinformatics. 2015 Oct 15;31(20):3356-8
pubmed: 26069265
J Immunol. 1991 Apr 1;146(7):2331-40
pubmed: 1706393
J Immunol. 2008 Dec 1;181(11):7853-62
pubmed: 19017975
Immunity. 2012 Oct 19;37(4):611-21
pubmed: 23063329
Nature. 2017 Jul 6;547(7661):89-93
pubmed: 28636592
Immunol Cell Biol. 2015 Oct;93(9):804-14
pubmed: 25804828
J Appl Crystallogr. 2007 Aug 1;40(Pt 4):658-674
pubmed: 19461840
Nat Rev Immunol. 2012 Sep;12(9):669-77
pubmed: 22918468
JCI Insight. 2017 Sep 7;2(17):
pubmed: 28878121
Nucleic Acids Res. 2004 Mar 19;32(5):1792-7
pubmed: 15034147
Nucleic Acids Res. 2009 Jul;37(Web Server issue):W202-8
pubmed: 19458158
J Clin Invest. 2016 Jun 1;126(6):2093-108
pubmed: 27111229
J Virol. 2010 Apr;84(7):3312-9
pubmed: 20071564
J Immunol Methods. 2012 Aug 31;382(1-2):203-10
pubmed: 22705983