Adult-onset Repeat Rhabdomyolysis with a Very Long-chain Acyl-CoA Dehydrogenase Deficiency Due to Compound Heterozygous ACADVL Mutations.


Journal

Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241

Informations de publication

Date de publication:
01 Nov 2020
Historique:
pubmed: 17 7 2020
medline: 23 3 2021
entrez: 17 7 2020
Statut: ppublish

Résumé

Very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency is a genetic disorder of fatty acid beta oxidation that is caused by a defect in ACADVL, which encodes VLCAD. The clinical presentation of VLCAD deficiency is heterogeneous, and either a delayed diagnosis or a misdiagnosis may sometimes occur. We herein describe a difficult-to-diagnose case of the muscle form of adult-onset VLCAD deficiency with compound heterozygous ACADVL mutations including c.790A>G (p.K264E) and c.1246G>A (p.A416T).

Identifiants

pubmed: 32669490
doi: 10.2169/internalmedicine.4604-20
pmc: PMC7691026
doi:

Substances chimiques

Acyl-CoA Dehydrogenase, Long-Chain EC 1.3.8.8

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2729-2732

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Auteurs

Yasuhiro Fuseya (Y)

Department of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto University, Japan.
Department of Neurology, Graduate School of Medicine, Kyoto University Hospital, Japan.

Takeyo Sakurai (T)

Sakurai Clinic, Japan.

Jun-Ichi Miyahara (JI)

Department of Neurology, Tominaga Hospital, Japan.

Kei Sato (K)

Department of Neurology, Uji Hospital, Japan.

Seiji Kaji (S)

Department of Neurology, Graduate School of Medicine, Kyoto University Hospital, Japan.
Department of Neurology, Japanese Red Cross Wakayama Medical Center, Japan.

Yoshihiko Saito (Y)

Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan.

Makio Takahashi (M)

Department of Neurology, Japanese Red Cross Osaka Hospital, Japan.

Ichizo Nishino (I)

Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan.

Tokiko Fukuda (T)

Department of Pediatrics, Hamamatsu University School of Medicine, Japan.

Hideo Sugie (H)

Faculty of Health and Medical Sciences, Tokoha University, Japan.

Hirofumi Yamashita (H)

Department of Neurology, Japanese Red Cross Wakayama Medical Center, Japan.

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Classifications MeSH