Autonomic function in amnestic and non-amnestic mild cognitive impairment: spectral heart rate variability analysis provides evidence for a brain-heart axis.
Aged
Aged, 80 and over
Amnesia
/ diagnostic imaging
Attention
/ physiology
Autonomic Nervous System
/ diagnostic imaging
Cerebral Cortex
/ diagnostic imaging
Cognitive Dysfunction
/ diagnostic imaging
Cross-Sectional Studies
Dizziness
/ diagnostic imaging
Executive Function
/ physiology
Female
Heart
/ diagnostic imaging
Heart Rate
/ physiology
Hippocampus
/ diagnostic imaging
Humans
Male
Memory
/ physiology
Neuroimaging
Neuropsychological Tests
Postural Balance
/ physiology
Severity of Illness Index
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
15 07 2020
15 07 2020
Historique:
received:
24
01
2020
accepted:
15
06
2020
entrez:
17
7
2020
pubmed:
17
7
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Mild cognitive impairment (MCI) is a heterogeneous syndrome with two main clinical subtypes, amnestic (aMCI) and non-amnestic (naMCI). The analysis of heart rate variability (HRV) is a tool to assess autonomic function. Cognitive and autonomic processes are linked via the central autonomic network. Autonomic dysfunction entails several adverse outcomes. However, very few studies have investigated autonomic function in MCI and none have considered MCI subtypes or the relationship of HRV indices with different cognitive domains and structural brain damage. We assessed autonomic function during an active orthostatic challenge in 253 oupatients aged ≥ 65, [n = 82 aMCI, n = 93 naMCI, n = 78 cognitively normal (CN), neuropsychologically tested] with power spectral analysis of HRV. We used visual rating scales to grade cerebrovascular burden and hippocampal/insular atrophy (HA/IA) on neuroimaging. Only aMCI showed a blunted response to orthostasis. Postural changes in normalised low frequency (LF) power and in the LF to high frequency ratio correlated with a memory test (positively) and HA/IA (negatively) in aMCI, and with attention/executive function tests (negatively) and cerebrovascular burden (positively) in naMCI. These results substantiate the view that the ANS is differentially impaired in aMCI and naMCI, consistently with the neuroanatomic substrate of Alzheimer's and small-vessel subcortical ischaemic disease.
Identifiants
pubmed: 32669640
doi: 10.1038/s41598-020-68131-x
pii: 10.1038/s41598-020-68131-x
pmc: PMC7363846
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
11661Références
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