Glutamine metabolism in Th17/Treg cell fate: applications in Th17 cell-associated diseases.
Th17 cells
Treg cells
UDP-GlcNAc
glutamine
mTOR
Journal
Science China. Life sciences
ISSN: 1869-1889
Titre abrégé: Sci China Life Sci
Pays: China
ID NLM: 101529880
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
01
03
2020
accepted:
27
04
2020
pubmed:
17
7
2020
medline:
15
12
2021
entrez:
17
7
2020
Statut:
ppublish
Résumé
Alteration in the Th17/Treg cell balance is implicated in various autoimmune diseases and these disease-associated pathologies. Increasing investigations have shown that glutamine metabolism regulates the differentiation of Th17 and Treg cells. Here we summarize the mechanisms by which glutamine metabolism regulates Th17/Treg cell fate. Some examples of a glutamine metabolism-dependent modulation of the development and progression of several Th17 Treg cell-associated diseases are provided afterward. This review will provide a comprehensive understanding of the importance of glutamine metabolism in the fate of Th17 Treg cell differentiation.
Identifiants
pubmed: 32671630
doi: 10.1007/s11427-020-1703-2
pii: 10.1007/s11427-020-1703-2
doi:
Substances chimiques
Amino Acid Transport Systems
0
Glutamine
0RH81L854J
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
221-233Références
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