Downregulation of PGI
Bronchi
/ enzymology
Cell Hypoxia
/ physiology
Cells, Cultured
Cytochrome P-450 Enzyme System
/ metabolism
Dinoprost
/ metabolism
Down-Regulation
Epoprostenol
/ metabolism
Female
Humans
Hypertension, Pulmonary
/ enzymology
Intramolecular Oxidoreductases
/ metabolism
Lung
/ enzymology
Male
Muscle, Smooth, Vascular
/ enzymology
Pulmonary Artery
/ enzymology
Pulmonary Veins
/ enzymology
Distal lung tissue
Human pulmonary hypertension
PASMC
PGI(2)
Prostacyclin synthase
Pulmonary artery
Journal
Prostaglandins, leukotrienes, and essential fatty acids
ISSN: 1532-2823
Titre abrégé: Prostaglandins Leukot Essent Fatty Acids
Pays: Scotland
ID NLM: 8802730
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
15
02
2020
revised:
27
06
2020
accepted:
02
07
2020
pubmed:
17
7
2020
medline:
5
11
2020
entrez:
17
7
2020
Statut:
ppublish
Résumé
Pulmonary hypertension (PH) is a progressive and life-threating lung disorder characterized by elevated pulmonary artery pressure and vascular remodeling. PH is classified into five groups, and one of the most common and lethal forms, PH Group-III is defined as PH due to lung diseases and/or hypoxia. Due to the lack of studies in this group, PH-specific drug therapies including prostacyclin (PGI
Identifiants
pubmed: 32673988
pii: S0952-3278(20)30116-2
doi: 10.1016/j.plefa.2020.102158
pii:
doi:
Substances chimiques
6-keto-prostaglandin F2alpha
0
Cytochrome P-450 Enzyme System
9035-51-2
Dinoprost
B7IN85G1HY
Epoprostenol
DCR9Z582X0
Intramolecular Oxidoreductases
EC 5.3.-
prostacyclin synthetase
EC 5.3.99.4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102158Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.