Short Communication: Circulating Mitochondrial DNA and Lipopolysaccharide-Binding Protein but Not Bacterial DNA Are Increased in Acute Human Immunodeficiency Virus Infection.
LPS-binding protein
acute HIV infection
bacterial DNA
circulating mitochondrial DNA
droplet digital PCR
microbial translocation
Journal
AIDS research and human retroviruses
ISSN: 1931-8405
Titre abrégé: AIDS Res Hum Retroviruses
Pays: United States
ID NLM: 8709376
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
pubmed:
18
7
2020
medline:
19
8
2021
entrez:
18
7
2020
Statut:
ppublish
Résumé
Microbial translocation has been suggested as a major driver of chronic immune activation HIV infection. Thus, we compared the extent of microbial translocation in patients with acute HIV infection and patients followed after CD4-guided structured treatment interruption (STI) by measuring different circulating markers: (1) lipopolysaccharide (LPS)-binding protein (LBP), (2) bacterial DNA, (3) soluble CD14 (sCD14), and (4) mitochondrial DNA (mtDNA). Bacterial DNA and sCD14 levels were similar in all groups. Patients in acute phase showed higher levels of LBP and mtDNA. In STI, we found a positive correlation between the percentage of CD8+ T cells and bacterial DNA levels. Considering all patients, LBP was positively correlated with the percentage and the absolute count of CD8+ T cells, and with mtDNA stressing the importance of mitochondrial products in sustaining chronic immune activation.
Identifiants
pubmed: 32674583
doi: 10.1089/AID.2020.0098
doi:
Substances chimiques
Acute-Phase Proteins
0
Carrier Proteins
0
DNA, Bacterial
0
DNA, Mitochondrial
0
Lipopolysaccharide Receptors
0
Lipopolysaccharides
0
Membrane Glycoproteins
0
lipopolysaccharide-binding protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM