Atypical BCL6/GATA3+ Primary Cutaneous Acral CD8-Positive T-Cell Lymphoma: A Diagnostic Challenge.
Biomarkers, Tumor
/ analysis
Biopsy
CD8-Positive T-Lymphocytes
/ chemistry
Female
GATA3 Transcription Factor
/ analysis
Humans
Immunohistochemistry
Lymphocytes, Tumor-Infiltrating
/ chemistry
Lymphoma, T-Cell, Cutaneous
/ chemistry
Middle Aged
Proto-Oncogene Proteins c-bcl-6
/ analysis
Skin Neoplasms
/ chemistry
Treatment Outcome
Journal
The American Journal of dermatopathology
ISSN: 1533-0311
Titre abrégé: Am J Dermatopathol
Pays: United States
ID NLM: 7911005
Informations de publication
Date de publication:
01 02 2021
01 02 2021
Historique:
pubmed:
18
7
2020
medline:
18
7
2020
entrez:
18
7
2020
Statut:
ppublish
Résumé
Primary cutaneous acral CD8-positive T-cell lymphoma consists of slow-growing nodules in acral sites with a histopathology, suggesting high-grade lymphoma despite the indolent clinical course. It has been recently included in WHO-EORTC classification for primary cutaneous lymphomas as a provisional entity. A correct diagnosis of this entity is important because its differential diagnosis include more aggressive cutaneous lymphomas. We present a 53-year-old woman with an indolent solitary nodule on her right leg, which histopathologically showed features of CD8-positive T-cell lymphoma, although with some peculiarities, including epidermotropism, absence of CD68 expression, and positivity for GATA3 and Bcl6 in neoplastic cells. This case could contribute to better define the spectrum of this rare cutaneous lymphoma.
Identifiants
pubmed: 32675470
pii: 00000372-202102000-00006
doi: 10.1097/DAD.0000000000001737
doi:
Substances chimiques
BCL6 protein, human
0
Biomarkers, Tumor
0
GATA3 Transcription Factor
0
GATA3 protein, human
0
Proto-Oncogene Proteins c-bcl-6
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
137-140Informations de copyright
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
M.A. Piris is sponsored by TAKEDA. The remaining authors declare no conflicts of interest.
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