Effectiveness of Acupuncture Treatment on Chemotherapy-Induced Peripheral Neuropathy: A Pilot, Randomized, Assessor-Blinded, Controlled Trial.
Acupuncture Therapy
/ adverse effects
Adult
Analgesics
/ therapeutic use
Antineoplastic Agents
/ adverse effects
China
Female
Gabapentin
/ therapeutic use
Humans
Iran
Male
Middle Aged
Pilot Projects
Polyneuropathies
/ chemically induced
Single-Blind Method
Thiamine
/ therapeutic use
Treatment Outcome
Vitamin B Complex
/ therapeutic use
Journal
Pain research & management
ISSN: 1918-1523
Titre abrégé: Pain Res Manag
Pays: United States
ID NLM: 9612504
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
10
2019
revised:
12
05
2020
accepted:
06
06
2020
entrez:
18
7
2020
pubmed:
18
7
2020
medline:
24
11
2020
Statut:
epublish
Résumé
This pilot study aims to evaluate the effectiveness and safety of acupuncture in the treatment of chemotherapy-induced peripheral neuropathy (CIPN). This study was a pilot randomized controlled trial, which was conducted with cooperation between Beijing University of Chinese Medicine (BUCM), China, and Tehran University of Medical Science (TUMS), Iran. Forty participants with CIPN were randomly assigned (1 : 1) to receive twelve sessions of acupuncture (20 minutes each session over 4 weeks) or take one 300 mg tablet of vitamin B1 and three 300 mg capsules of gabapentin per day for 4 weeks, after which both groups were followed up for 4 weeks. The primary endpoint was CIPN symptom severity measured by the Numerical Rating Scale (NRS). The secondary endpoints included sensory neuropathy grade evaluated by the National Cancer Institute-Common Toxicity Criteria for Adverse Events (NCI-CTCAE), neurophysiological assessment of CIPN by the nerve conduction study (NCS), and the patient overall satisfaction with treatment. Safety was assessed at each visit. The NRS and NCI-CTCAE sensory neuropathy grading scales decreased significantly over time in both groups (both Our study revealed that acupuncture, as a kind of traditional Chinese therapeutic method, is significantly effective and safe in the treatment of CIPN. Moreover, acupuncture is more effective than using vitamin B1 and gabapentin as the conventional treatment.
Identifiants
pubmed: 32676134
doi: 10.1155/2020/2504674
pmc: PMC7341378
doi:
Substances chimiques
Analgesics
0
Antineoplastic Agents
0
Vitamin B Complex
12001-76-2
Gabapentin
6CW7F3G59X
Thiamine
X66NSO3N35
Banques de données
IRCT
['IRCT20190615043900N1']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2504674Informations de copyright
Copyright © 2020 Somayeh Iravani et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
Références
Chin J Integr Med. 2013 Jan;19(1):58-67
pubmed: 23275016
Pain. 2009 Dec;146(3):238-44
pubmed: 19836888
Front Mol Neurosci. 2017 May 31;10:174
pubmed: 28620280
Curr Oncol. 2016 Feb;23(1):e27-34
pubmed: 26966410
Trials. 2013 Aug 14;14:254
pubmed: 23945074
Complement Ther Med. 2007 Dec;15(4):228-37
pubmed: 18054724
Acupunct Med. 2007 Jun;25(1-2):11-7
pubmed: 17641562
Am J Clin Oncol. 1996 Aug;19(4):394-9
pubmed: 8677913
Evid Based Complement Alternat Med. 2016;2016:9874207
pubmed: 27403201
Evid Based Complement Alternat Med. 2018 Oct 21;2018:5367014
pubmed: 30420895
Ann Oncol. 2013 Feb;24(2):454-62
pubmed: 22910842
Pain. 2014 Dec;155(12):2461-70
pubmed: 25261162
Pain Res Treat. 2011;2011:920807
pubmed: 22110934
J Acupunct Meridian Stud. 2010 Jun;3(2):95-103
pubmed: 20633522
Pain. 2001 Nov;94(2):149-58
pubmed: 11690728
Expert Rev Anticancer Ther. 2017 Nov;17(11):1045-1060
pubmed: 28868935
BMC Cancer. 2017 Jan 9;17(1):40
pubmed: 28068938
J Tradit Chin Med. 2010 Mar;30(1):13-4
pubmed: 20397454
JAMA. 2000 Dec 6;284(21):2755-61
pubmed: 11105182
CA Cancer J Clin. 2013 Nov-Dec;63(6):419-37
pubmed: 24590861
Int J Clin Oncol. 2015 Oct;20(5):866-71
pubmed: 25762165
FASEB J. 2001 Oct;15(12):2275-82
pubmed: 11641255
JAMA Netw Open. 2020 Mar 2;3(3):e200681
pubmed: 32159808
Eur J Cancer Care (Engl). 2017 Mar;26(2):
pubmed: 26853524
Acupunct Med. 2006 Jun;24(2):87-91
pubmed: 16783284
Curr Med Chem. 2019;26(25):4698-4708
pubmed: 30621553
Lasers Med Sci. 2002;17(1):19-25
pubmed: 11845364
Evid Based Complement Alternat Med. 2016;2016:2421876
pubmed: 27795728
BMJ Support Palliat Care. 2019 Jun 29;:
pubmed: 31256014
Integr Cancer Ther. 2019 Jan-Dec;18:1534735419836501
pubmed: 30905173
Integr Cancer Ther. 2010 Jun;9(2):158-67
pubmed: 20483875
J Clin Oncol. 2004 May 1;22(9):1731-5
pubmed: 15117996
J Tradit Chin Med. 2017 Apr;37(2):179-84
pubmed: 29960289
J Clin Oncol. 2014 Jun 20;32(18):1941-67
pubmed: 24733808
Trends Neurosci. 2003 Jan;26(1):17-22
pubmed: 12495858
Acupunct Med. 2014 Apr;32(2):194-6
pubmed: 24389811
Integr Cancer Ther. 2019 Jan-Dec;18:1534735419886662
pubmed: 31833790
Acupunct Med. 2012 Mar;30(1):4-7
pubmed: 22146780
Evid Based Complement Alternat Med. 2013;2013:516916
pubmed: 23983788
J Altern Complement Med. 2004 Jun;10(3):449-55
pubmed: 15253848
Acupunct Med. 2011 Sep;29(3):230-3
pubmed: 21875929
J Acupunct Meridian Stud. 2014 Dec;7(6):331-6
pubmed: 25499567
Integr Cancer Ther. 2014 Sep;13(5):371-85
pubmed: 24501113
Evid Based Complement Alternat Med. 2013;2013:349653
pubmed: 24066010
Anesth Analg. 2007 Feb;104(2):301-7
pubmed: 17242084
Diabetes Res Clin Pract. 1998 Feb;39(2):115-21
pubmed: 9597381