Quantifying Genetic and Environmental Influence on Gray Matter Microstructure Using Diffusion MRI.
MSD
RTOP
imaging genetics
non-Gaussian model
twin study
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
03 11 2020
03 11 2020
Historique:
received:
18
11
2019
revised:
28
05
2020
accepted:
28
05
2020
pubmed:
18
7
2020
medline:
16
12
2021
entrez:
18
7
2020
Statut:
ppublish
Résumé
Early neuroimaging work in twin studies focused on studying genetic and environmental influence on gray matter macrostructure. However, it is also important to understand how gray matter microstructure is influenced by genes and environment to facilitate future investigations of their influence in mental disorders. Advanced diffusion MRI (dMRI) measures allow more accurate assessment of gray matter microstructure compared with conventional diffusion tensor measures. To understand genetic and environmental influence on gray matter, we used diffusion and structural MRI data from a large twin and sibling study (N = 840) and computed advanced dMRI measures including return to origin probability (RTOP), which is heavily weighted toward intracellular and intra-axonal restricted spaces, and mean squared displacement (MSD), more heavily weighted to diffusion in extracellular space and large cell bodies in gray matter. We show that while macrostructural features like brain volume are mainly genetically influenced, RTOP and MSD can together tap into both genetic and environmental influence on microstructure.
Identifiants
pubmed: 32676671
pii: 5872616
doi: 10.1093/cercor/bhaa174
pmc: PMC7732156
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Twin Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
6191-6205Subventions
Organisme : NIMH NIH HHS
ID : R01 MH119222
Pays : United States
Organisme : NIMH NIH HHS
ID : K24 MH110807
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH112748
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH102377
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG042512
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH111917
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH115247
Pays : United States
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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