Infarct growth patterns may vary in acute stroke due to large vessel occlusion and recanalization with endovascular therapy.
Aged
Arterial Occlusive Diseases
/ complications
Brain Infarction
/ etiology
Carotid Artery, Internal
/ diagnostic imaging
Databases, Factual
Diffusion Magnetic Resonance Imaging
/ methods
Endovascular Procedures
/ methods
Female
Humans
Male
Middle Cerebral Artery
/ diagnostic imaging
Prospective Studies
Registries
Republic of Korea
Stroke
/ diagnostic imaging
Treatment Outcome
Cerebral infarction
Diffusion
Stroke
Thrombectomy
Journal
European radiology
ISSN: 1432-1084
Titre abrégé: Eur Radiol
Pays: Germany
ID NLM: 9114774
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
08
01
2020
accepted:
03
07
2020
revised:
27
04
2020
pubmed:
18
7
2020
medline:
1
4
2021
entrez:
18
7
2020
Statut:
ppublish
Résumé
This study aimed to investigate infarct growth patterns in stroke patients with large vessel occlusion (LVO) and successful recanalization by endovascular therapy (EVT). A total of 135 patients with LVO of the internal carotid artery or proximal segment of the middle cerebral artery admitted within 12 h after onset, having baseline National Institute of Health Stroke Scale score ≥ 5 points, and successfully recanalized by EVT were enrolled. Infarct growth pattern models were developed based on infarct volumes on diffusion-weighted imaging before and after reperfusion. Single pattern models of linear, logarithmic, and exponential shapes were initially tested. Their appropriateness was predetermined. If none of these patterns was suitable, the best pattern model, which was the most suitable pattern among the three shapes selected for each individual, was tested. Clinical correlates were explored. Each single pattern model was tested for their suitability. However, none of the single pattern models successfully represented infarct growth curves: Of all subjects, only 63.7%, 62.2%, and 54.1% of patients were explained by the logarithmic, linear, and exponential model, respectively. Compared with the single pattern models, the best pattern model explained 80.7% of the subjects. The linear shape fit best in 40 patients, the logarithmic in 51, and the exponential in 44. Those fit best for the logarithmic pattern showed more favorable outcomes at discharge (31.4%) than did the others (linear, 10.0%; exponential, 9.1%; p = 0.01). Infarct growth patterns may vary among individual patients with acute stroke due to LVO and successful treatment with EVT. • Infarct growth during the acute stage of stroke is highly dynamic and the exact shape remains unknown. • Infarct growth pattern models were developed based on infarct volumes on diffusion-weighted imaging before and after reperfusion. • Infarct growth patterns may not be singular, rather various among individual patients with acute stroke due to LVO and successful treatment with EVT.
Identifiants
pubmed: 32676782
doi: 10.1007/s00330-020-07068-1
pii: 10.1007/s00330-020-07068-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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