Chiral auxiliaries: Usefullness in stereoselective glycosylation reactions and their synthetic applications.
1,2-Cis glycosidic bonds
Chiral auxiliary
Glycosylation
Oligosaccharides
Stereoselective
Journal
Carbohydrate research
ISSN: 1873-426X
Titre abrégé: Carbohydr Res
Pays: Netherlands
ID NLM: 0043535
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
25
02
2020
revised:
07
05
2020
accepted:
22
05
2020
pubmed:
18
7
2020
medline:
1
6
2021
entrez:
18
7
2020
Statut:
ppublish
Résumé
Oligosaccharides play a very important role in biological system and structure-activity relationships that is why it has a lot of application to medicinal chemistry and development of polysaccharide conjugate vaccines. The stereoselective introduction of a glycosidic linkage presents the principal challenge for biological importance oligosaccharide synthesis. The main aim of this review is to described the importance of chiral auxiliary and neibhouring group participation for the stereoselective 1,2-cis glycosidic bonds formation and their application in complex oligosaccharide synthesis.Numerous 1,2-cis-linked oligosaccharides and glyconjugates are naturally found in the compounds of blood group, human milk, antigens of bacterial lipopolysaccharide etc.that predominantly increased it's importance in this field.
Identifiants
pubmed: 32679340
pii: S0008-6215(20)30117-8
doi: 10.1016/j.carres.2020.108045
pii:
doi:
Substances chimiques
Glycosides
0
Oligosaccharides
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
108045Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.