Interactions of insulin with tragacanthic acid biopolymer: Experimental and computational study.
Docking
Drug delivery
Insulin
Interaction
Molecular dynamics
Tragacanthic acid
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
01 Dec 2020
01 Dec 2020
Historique:
received:
19
03
2020
revised:
11
07
2020
accepted:
12
07
2020
pubmed:
19
7
2020
medline:
13
4
2021
entrez:
19
7
2020
Statut:
ppublish
Résumé
Alternative methods for insulin delivery instead of subcutaneous injection in diabetic patients is of great essential, and biocompatible polymers are one of the most efficient vehicles for this purpose. This research aims to investigate the capability of tragacanthic acid (TA) to bind insulin and release it under physiological conditions without alteration in the structure and conformation of insulin. Interactions between TA and insulin were studied using spectroscopic techniques and computational modeling by docking and molecular dynamics simulations. Our results demonstrate an entropy-driven spontaneous interaction between insulin and TA, where hydrogen bonds act as the main enthalpic contribution. According to our findings, the weak interaction between insulin and TA provides the basis for efficient capture and appropriate release of insulin by TA as a potential part of the insulin delivery system. In conclusion, tragacanth acid can be a proper candidate for insulin delivery.
Identifiants
pubmed: 32682034
pii: S0141-8130(20)33875-7
doi: 10.1016/j.ijbiomac.2020.07.122
pii:
doi:
Substances chimiques
Acids
0
Biopolymers
0
Insulin
0
Tragacanth
9000-65-1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
321-330Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.