TREM-1 and TREM-2 Expression on Blood Monocytes Could Help Predict Survival in High-Grade Glioma Patients.
Adult
Aged
Female
Glioma
/ blood
HMGB1 Protein
/ blood
Humans
Interleukin-10
/ blood
Interleukin-6
/ blood
Lipopolysaccharide Receptors
/ metabolism
Male
Membrane Glycoproteins
/ metabolism
Middle Aged
Monocytes
/ metabolism
Proportional Hazards Models
Receptors, Immunologic
/ metabolism
Triggering Receptor Expressed on Myeloid Cells-1
/ metabolism
Journal
Mediators of inflammation
ISSN: 1466-1861
Titre abrégé: Mediators Inflamm
Pays: United States
ID NLM: 9209001
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
02
2020
revised:
27
04
2020
accepted:
25
05
2020
entrez:
21
7
2020
pubmed:
21
7
2020
medline:
22
6
2021
Statut:
epublish
Résumé
In recent years, the role of the modern inflammatory markers TREM-1 (triggering receptors expressed on myeloid cells) and HMGB1 (high mobility group box 1 protein) in tumorigenesis has begun to be studied. Their role in gliomas is not clear. The aim of our study was to find the role of inflammation in gliomas. Cox proportional hazard analysis showed that a TREM-1/TREM-2 ratio was associated with reduced overall survival (HR = 1.001, We showed that the TREM-1/TREM-2 ratio (expression on the surface of blood monocytes) could help predict prognosis in patients with gliomas, especially in high-grade gliomas, and that systemic inflammation has an impact on the patient's overall survival. This is the first study that showed that TREM expression on monocytes in peripheral blood could help predict prognosis in patients with gliomas.
Identifiants
pubmed: 32684831
doi: 10.1155/2020/1798147
pmc: PMC7350089
doi:
Substances chimiques
HMGB1 Protein
0
IL10 protein, human
0
Interleukin-6
0
Lipopolysaccharide Receptors
0
Membrane Glycoproteins
0
Receptors, Immunologic
0
TREM2 protein, human
0
Triggering Receptor Expressed on Myeloid Cells-1
0
Interleukin-10
130068-27-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1798147Informations de copyright
Copyright © 2020 K. Kluckova et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest regarding the publication of this article.
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