Impact of white-spotting alleles, including W20, on phenotype in the American Paint Horse.
ASIP
KIT
MC1R
coat color
pigmentation
registration
Journal
Animal genetics
ISSN: 1365-2052
Titre abrégé: Anim Genet
Pays: England
ID NLM: 8605704
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
accepted:
02
05
2020
pubmed:
21
7
2020
medline:
19
12
2020
entrez:
21
7
2020
Statut:
ppublish
Résumé
The American Paint Horse Association (APHA) records pedigree and performance information for their breed, a stock-type horse valued as a working farm or ranch horse and as a pleasure horse. As the name implies, the breed is also valued for its attractive white-spotting patterns on the coat. The APHA utilizes visual inspections of photographs to determine if coat spotting exceeds threshold anatomical landmarks considered characteristic of desirable patterns. Horses with sufficient white patterning enter the 'Regular' registry, rather than the 'Solid Paint-Bred' division, providing a threshold modeled phenotype. Genetic studies previously defined sequence variants corresponding to 35 alleles for white spotting in the horse. Here, we calculate the allele frequencies for nine common white-spotting alleles in the American Paint Horse using a sample of 1054 registered animals. The APHA spotting phenotype is altered by additive interactions among spotting loci, and epistatically by the MC1R and ASIP genes controlling pigment production. The W20 allele within the KIT gene, independent of other known spotting alleles, was strongly associated with the APHA-defined white-spotting phenotype (P = 1.86 × 10
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
707-715Subventions
Organisme : American Paint Horse Association
Informations de copyright
© 2020 Stichting International Foundation for Animal Genetics.
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