DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors.


Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
20 07 2020
Historique:
received: 02 03 2020
accepted: 20 07 2020
pubmed: 21 7 2020
medline: 17 2 2021
entrez: 21 7 2020
Statut: epublish

Résumé

Fertility across metazoa requires the germline-specific DAZ family of RNA-binding proteins. Here we examine whether DAZL directly regulates progenitor spermatogonia using a conditional genetic mouse model and in vivo biochemical approaches combined with chemical synchronization of spermatogenesis. We find that the absence of

Identifiants

pubmed: 32686646
doi: 10.7554/eLife.56523
pii: 56523
pmc: PMC7445011
doi:
pii:

Substances chimiques

3' Untranslated Regions 0
DAZL protein, mouse 0
RNA-Binding Proteins 0

Banques de données

GEO
['GSE144919', 'GSE144923', 'GSE144920', 'GSE144922', 'GSE145177', 'GSE102783', 'GSE107124', 'GSE108183', 'GSE125483']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIGMS NIH HHS
ID : T32 GM007287
Pays : United States
Organisme : National Health and Medical Research Council
ID : GNT1053776
Pays : International
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : National Key Research and Development Program of China
ID : 2017YFC1001600
Pays : International
Organisme : National Natural Science Foundation of China
ID : 81471507
Pays : International
Organisme : Hope Funds for Cancer Research
ID : HFCR-15-06-06
Pays : International
Organisme : NICHD NIH HHS
ID : F32 HD093391
Pays : United States

Informations de copyright

© 2020, Mikedis et al.

Déclaration de conflit d'intérêts

MM, YF, PN, TE, EJ, SC, Dd, DP No competing interests declared

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Auteurs

Maria M Mikedis (MM)

Whitehead Institute, Cambridge, United States.

Yuting Fan (Y)

Whitehead Institute, Cambridge, United States.
Reproductive Medicine Center, Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Peter K Nicholls (PK)

Whitehead Institute, Cambridge, United States.

Tsutomu Endo (T)

Whitehead Institute, Cambridge, United States.

Emily K Jackson (EK)

Whitehead Institute, Cambridge, United States.
Department of Biology, Massachusetts Institute of Technology, Cambridge, United States.

Sarah A Cobb (SA)

Whitehead Institute, Cambridge, United States.

Dirk G de Rooij (DG)

Whitehead Institute, Cambridge, United States.

David C Page (DC)

Whitehead Institute, Cambridge, United States.
Department of Biology, Massachusetts Institute of Technology, Cambridge, United States.
Howard Hughes Medical Institute, Whitehead Institute, Cambridge, United States.

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Classifications MeSH