Normal insulin sensitivity, glucose tolerance, gut incretin and pancreatic hormone responses in adults with atopic dermatitis.
clinical physiology, clinical trial, insulin resistance
Journal
Diabetes, obesity & metabolism
ISSN: 1463-1326
Titre abrégé: Diabetes Obes Metab
Pays: England
ID NLM: 100883645
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
14
05
2020
revised:
03
07
2020
accepted:
16
07
2020
pubmed:
21
7
2020
medline:
25
6
2021
entrez:
21
7
2020
Statut:
ppublish
Résumé
To examine whether adults with mild to moderate atopic dermatitis (AD) had reduced insulin sensitivity and/or exhibited other gluco-metabolic disturbances compared with carefully matched healthy controls. Sixteen adult, non-obese, non-diabetic patients with mild to moderate AD and 16 gender-, age- and body mass index (BMI)-matched healthy controls underwent a hyperinsulinaemic euglycaemic clamp (insulin infusion rate: 40 mU/m The two groups were similar in age (33 ± 3 vs. 33 ± 3 years, mean ± standard error of the mean [SEM]), gender (56% women), BMI (24.5 ± 0.7 vs. 24.4 ± 0.7 kg/m Using OGTT and the hyperinsulinaemic euglycaemic clamp technique, we found no difference in insulin sensitivity or other gluco-metabolic characteristics between patients with mild to moderate AD and matched healthy controls, suggesting that the inflammatory skin disease AD has little or no influence on glucose metabolism.
Substances chimiques
Blood Glucose
0
Incretins
0
Insulin
0
Pancreatic Hormones
0
Gastric Inhibitory Polypeptide
59392-49-3
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2161-2169Subventions
Organisme : Aase og Ejnar Danielsens Fond
Pays : International
Organisme : Kongelig Hofbuntmager Aage Bangs Fond
Pays : International
Organisme : Sundhed og Sygdom, Det Frie Forskningsråd
Pays : International
Organisme : Gentofte Hospital
Pays : International
Informations de copyright
© 2020 John Wiley & Sons Ltd.
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