A global sensitivity analysis approach applied to a multiscale model of microvascular flow.

Computer Simulation Microcirculation / physiology Microvessels / physiology Models, Cardiovascular
Global sensitivity analysis microcirculation multiscale/multiphysics models numerical simulations

Journal

Computer methods in biomechanics and biomedical engineering
ISSN: 1476-8259
Titre abrégé: Comput Methods Biomech Biomed Engin
Pays: England
ID NLM: 9802899

Informations de publication

Date de publication:
Nov 2020
Historique:
pubmed: 21 7 2020
medline: 16 1 2021
entrez: 21 7 2020
Statut: ppublish

Résumé

A global sensitivity analysis of a multiscale computational model of microvascular flow is presented. A total of 140 simulations have been completed and analyzed varying 6 input parameters and considering their effects on 7 output variables. Interestingly, the vascular network topology has been found as a determinant factor for both vasculature-related and interstitium-related quantities. Regarding the firsts, the vascular network topology has obtained a score of 5.5/6 and 6/6 for average and spatial distribution respectively (where 6 is the maximum and 1 is the minimum). On the other hand, considering interstitium-related quantities, the score is 4/6 and 5/6 for average and spatial distribution respectively. These results suggest that the network topology has a significant influence on the outcome of the computational analysis.

Identifiants

DOI: 10.1080/10255842.2020.1793964 PMID: 32687401
pubmed: 32687401
doi: 10.1080/10255842.2020.1793964
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1215-1224

Auteurs

L Possenti (L)

LaBS, Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Milan, Italy.
Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
ORCID: 0000-0003-4248-6371

S Di Gregorio (S)

MOX, Department of Mathematics, Politecnico di Milano, Milan, Italy.
ORCID: 0000-0001-5875-5359

G Casagrande (G)

LaBS, Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Milan, Italy.

M L Costantino (ML)

LaBS, Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Milan, Italy.

T Rancati (T)

Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

P Zunino (P)

MOX, Department of Mathematics, Politecnico di Milano, Milan, Italy.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › A global sensitivity analysis approach applied...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Circulation sanguine › Microcirculation › A global sensitivity analysis approach applied...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Microvaisseaux › A global sensitivity analysis approach applied...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles cardiovasculaires › A global sensitivity analysis approach applied...