Characterization of permissive and non-permissive peptide insertion sites in chloramphenicol acetyltransferase.
Chloramphenicol acetyltransferase
Escherichia coli
Pentapeptide scanning mutagenesis
Journal
Microbial pathogenesis
ISSN: 1096-1208
Titre abrégé: Microb Pathog
Pays: England
ID NLM: 8606191
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
20
04
2020
revised:
02
06
2020
accepted:
10
07
2020
pubmed:
21
7
2020
medline:
22
6
2021
entrez:
21
7
2020
Statut:
ppublish
Résumé
The growing prevalence of antibiotic resistance in numerous pathogenic bacteria is a major public health concern and urgently requires the development of new therapeutic approaches. Multidrug resistant species that remain sensitive to chloramphenicol (CAM) treatment have engendered renewed interest in using this drug as a modern day antimicrobial agent. High-level resistance to CAM commonly is mediated by chloramphenicol acetyltransferase (CAT) which catalyzes the acetylation of CAM and renders the drug inactive. Of the three main types (CAT
Identifiants
pubmed: 32687937
pii: S0882-4010(20)30761-0
doi: 10.1016/j.micpath.2020.104395
pii:
doi:
Substances chimiques
Peptides
0
Chloramphenicol
66974FR9Q1
Chloramphenicol O-Acetyltransferase
EC 2.3.1.28
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104395Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.