Restraining and unleashing chromatin remodelers - structural information guides chromatin plasticity.
Journal
Current opinion in structural biology
ISSN: 1879-033X
Titre abrégé: Curr Opin Struct Biol
Pays: England
ID NLM: 9107784
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
27
03
2020
revised:
06
06
2020
accepted:
16
06
2020
pubmed:
22
7
2020
medline:
16
10
2021
entrez:
22
7
2020
Statut:
ppublish
Résumé
Chromatin remodeling enzymes are large molecular machines that guard the genome by reorganizing chromatin structure. They can reposition, space and evict nucleosomes and thus control gene expression, DNA replication and repair. Recent cryo-electron microscopy (cryo-EM) analyses have captured snapshots of various chromatin remodelers as they interact with nucleosomes. In this review, we summarize and discuss the advances made in our understanding of the regulation of chromatin remodelers, the mode of DNA translocation, as well as the influence of associated protein domains and remodeler subunits on the specific functions of chromatin remodeling complexes. The emerging structural information will help our understanding of disease mechanisms and guide our knowledge toward innovative therapeutic interventions.
Identifiants
pubmed: 32693313
pii: S0959-440X(20)30108-1
doi: 10.1016/j.sbi.2020.06.008
pii:
doi:
Substances chimiques
Chromatin
0
Nucleosomes
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
130-138Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.