Salvage autologous transplant and lenalidomide maintenance vs. lenalidomide/dexamethasone for relapsed multiple myeloma: the randomized GMMG phase III trial ReLApsE.

Adolescent Adult Aged Animals Antineoplastic Combined Chemotherapy Protocols / adverse effects Biomarkers Biopsy Bone Marrow / pathology Chromosome Aberrations Combined Modality Therapy Female Hematopoietic Stem Cell Transplantation / adverse effects Humans Kaplan-Meier Estimate Male Mice Middle Aged Multiple Myeloma / diagnosis Neoplasm Staging Prognosis Proportional Hazards Models Salvage Therapy Transplantation, Autologous Treatment Outcome Young Adult

Journal

Leukemia

ISSN: 1476-5551

Titre abrégé: Leukemia

Pays: England

ID NLM: 8704895

Informations de publication

Date de publication:
04 2021

Historique:

received: 12 04 2020

accepted: 23 06 2020

revised: 20 06 2020

pubmed: 23 7 2020

medline: 1 5 2021

entrez: 23 7 2020

Statut: ppublish

Résumé

The role of salvage high-dose chemotherapy and autologous stem cell transplantation (sHDCT/ASCT) for relapsed and/or refractory multiple myeloma (RRMM) in the era of continuous novel agent treatment has not been defined. This randomized, open-label, phase III, multicenter trial randomized patients with 1st-3rd relapse of multiple myeloma (MM) to a transplant arm (n = 139) consisting of 3 Rd (lenalidomide 25 mg, day 1-21; dexamethasone 40 mg, day 1, 8, 15, and 22; 4-week cycles) reinduction cycles, sHDCT (melphalan 200 mg/m

Identifiants

DOI: 10.1038/s41375-020-0948-0 PMID: 32694619

pubmed: 32694619

doi: 10.1038/s41375-020-0948-0

pii: 10.1038/s41375-020-0948-0

doi:

Substances chimiques

Biomarkers 0

Types de publication

Clinical Trial, Phase III Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

1134-1144

Références

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